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Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis

Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients globally. Several databases, including Cochrane, EBSCO...

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Autores principales: Rani, Isha, Satapathy, Prakasini, Goyal, Anmol, Shamim, Muhammad Aaqib, Pal, Amit, Squitti, Rosanna, Goswami, Kalyan, Pradhan, Keerti Bhusan, Rustagi, Sarvesh, Hermis, Alaa Hamza, Barboza, Joshuan J., Rodriguez-Morales, Alfonso J., Sah, Ranjit, Padhi, Bijaya K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301466/
https://www.ncbi.nlm.nih.gov/pubmed/37376686
http://dx.doi.org/10.3390/v15061386
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author Rani, Isha
Satapathy, Prakasini
Goyal, Anmol
Shamim, Muhammad Aaqib
Pal, Amit
Squitti, Rosanna
Goswami, Kalyan
Pradhan, Keerti Bhusan
Rustagi, Sarvesh
Hermis, Alaa Hamza
Barboza, Joshuan J.
Rodriguez-Morales, Alfonso J.
Sah, Ranjit
Padhi, Bijaya K.
author_facet Rani, Isha
Satapathy, Prakasini
Goyal, Anmol
Shamim, Muhammad Aaqib
Pal, Amit
Squitti, Rosanna
Goswami, Kalyan
Pradhan, Keerti Bhusan
Rustagi, Sarvesh
Hermis, Alaa Hamza
Barboza, Joshuan J.
Rodriguez-Morales, Alfonso J.
Sah, Ranjit
Padhi, Bijaya K.
author_sort Rani, Isha
collection PubMed
description Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients globally. Several databases, including Cochrane, EBSCOHost, EMBASE, ProQuest, PubMed, Scopus, and Web of Science, and preprint servers were searched concerning skin mpox viral loads in confirmed mpox subjects. In this systematic review and meta-analysis, a total of 331 articles were initially screened after the removal of duplicate entries. A total of nine articles were included in the systematic review and meta-analysis for the overall estimation of viral loads (Ct) using a random-effect model. The pooled cutaneous mpox viral load (lower Ct) was 21.71 (95% CI: 20.68–22.75) with a majority of positivity rates being 100%, highlighting a higher infectivity risk from skin lesions. The current results strongly support that skin mpox viral loads may be a dominant source of rapid transmission during current multi-national outbreaks. This important finding can help in constructing useful measures in relevant health policy.
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spelling pubmed-103014662023-06-29 Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis Rani, Isha Satapathy, Prakasini Goyal, Anmol Shamim, Muhammad Aaqib Pal, Amit Squitti, Rosanna Goswami, Kalyan Pradhan, Keerti Bhusan Rustagi, Sarvesh Hermis, Alaa Hamza Barboza, Joshuan J. Rodriguez-Morales, Alfonso J. Sah, Ranjit Padhi, Bijaya K. Viruses Systematic Review Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients globally. Several databases, including Cochrane, EBSCOHost, EMBASE, ProQuest, PubMed, Scopus, and Web of Science, and preprint servers were searched concerning skin mpox viral loads in confirmed mpox subjects. In this systematic review and meta-analysis, a total of 331 articles were initially screened after the removal of duplicate entries. A total of nine articles were included in the systematic review and meta-analysis for the overall estimation of viral loads (Ct) using a random-effect model. The pooled cutaneous mpox viral load (lower Ct) was 21.71 (95% CI: 20.68–22.75) with a majority of positivity rates being 100%, highlighting a higher infectivity risk from skin lesions. The current results strongly support that skin mpox viral loads may be a dominant source of rapid transmission during current multi-national outbreaks. This important finding can help in constructing useful measures in relevant health policy. MDPI 2023-06-17 /pmc/articles/PMC10301466/ /pubmed/37376686 http://dx.doi.org/10.3390/v15061386 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Rani, Isha
Satapathy, Prakasini
Goyal, Anmol
Shamim, Muhammad Aaqib
Pal, Amit
Squitti, Rosanna
Goswami, Kalyan
Pradhan, Keerti Bhusan
Rustagi, Sarvesh
Hermis, Alaa Hamza
Barboza, Joshuan J.
Rodriguez-Morales, Alfonso J.
Sah, Ranjit
Padhi, Bijaya K.
Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis
title Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis
title_full Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis
title_fullStr Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis
title_full_unstemmed Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis
title_short Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis
title_sort viral loads in skin samples of patients with monkeypox virus infection: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301466/
https://www.ncbi.nlm.nih.gov/pubmed/37376686
http://dx.doi.org/10.3390/v15061386
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