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Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release

Luteolin (LUT) is a flavonoid found in several edible and medicinal plants. It is recognized for its biological activities such as antioxidant, anti-inflammatory, neuroprotective, and antitumor effects. However, the limited water solubility of LUT leads to poor absorption after oral administration....

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Autores principales: Diedrich, Camila, Zittlau, Isabella C., Khalil, Najeh M., Leontowich, Adam F. G., de Freitas, Rilton A., Badea, Ildiko, Mainardes, Rubiana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301769/
https://www.ncbi.nlm.nih.gov/pubmed/37376041
http://dx.doi.org/10.3390/pharmaceutics15061592
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author Diedrich, Camila
Zittlau, Isabella C.
Khalil, Najeh M.
Leontowich, Adam F. G.
de Freitas, Rilton A.
Badea, Ildiko
Mainardes, Rubiana M.
author_facet Diedrich, Camila
Zittlau, Isabella C.
Khalil, Najeh M.
Leontowich, Adam F. G.
de Freitas, Rilton A.
Badea, Ildiko
Mainardes, Rubiana M.
author_sort Diedrich, Camila
collection PubMed
description Luteolin (LUT) is a flavonoid found in several edible and medicinal plants. It is recognized for its biological activities such as antioxidant, anti-inflammatory, neuroprotective, and antitumor effects. However, the limited water solubility of LUT leads to poor absorption after oral administration. Nanoencapsulation may improve the solubility of LUT. Nanoemulsions (NE) were selected for the encapsulation of LUT due to their biodegradability, stability, and ability to control drug release. In this work, chitosan (Ch)-based NE was developed to encapsulate luteolin (NECh-LUT). A 2(3) factorial design was built to obtain a formulation with optimized amounts of oil, water, and surfactants. NECh-LUT showed a mean diameter of 67.5 nm, polydispersity index 0.174, zeta potential of +12.8 mV, and encapsulation efficiency of 85.49%. Transmission electron microscopy revealed spherical shape and rheological analysis verified the Newtonian behavior of NECh-LUT. SAXS technique confirmed the bimodal characteristic of NECh-LUT, while stability analysis confirmed NECh-LUT stability when stored at room temperature for up to 30 days. Finally, in vitro release studies showed LUT controlled release up to 72 h, indicating the promising potential of NECh-LUT to be used as novel therapeutic option to treat several disorders.
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spelling pubmed-103017692023-06-29 Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release Diedrich, Camila Zittlau, Isabella C. Khalil, Najeh M. Leontowich, Adam F. G. de Freitas, Rilton A. Badea, Ildiko Mainardes, Rubiana M. Pharmaceutics Article Luteolin (LUT) is a flavonoid found in several edible and medicinal plants. It is recognized for its biological activities such as antioxidant, anti-inflammatory, neuroprotective, and antitumor effects. However, the limited water solubility of LUT leads to poor absorption after oral administration. Nanoencapsulation may improve the solubility of LUT. Nanoemulsions (NE) were selected for the encapsulation of LUT due to their biodegradability, stability, and ability to control drug release. In this work, chitosan (Ch)-based NE was developed to encapsulate luteolin (NECh-LUT). A 2(3) factorial design was built to obtain a formulation with optimized amounts of oil, water, and surfactants. NECh-LUT showed a mean diameter of 67.5 nm, polydispersity index 0.174, zeta potential of +12.8 mV, and encapsulation efficiency of 85.49%. Transmission electron microscopy revealed spherical shape and rheological analysis verified the Newtonian behavior of NECh-LUT. SAXS technique confirmed the bimodal characteristic of NECh-LUT, while stability analysis confirmed NECh-LUT stability when stored at room temperature for up to 30 days. Finally, in vitro release studies showed LUT controlled release up to 72 h, indicating the promising potential of NECh-LUT to be used as novel therapeutic option to treat several disorders. MDPI 2023-05-25 /pmc/articles/PMC10301769/ /pubmed/37376041 http://dx.doi.org/10.3390/pharmaceutics15061592 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Diedrich, Camila
Zittlau, Isabella C.
Khalil, Najeh M.
Leontowich, Adam F. G.
de Freitas, Rilton A.
Badea, Ildiko
Mainardes, Rubiana M.
Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
title Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
title_full Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
title_fullStr Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
title_full_unstemmed Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
title_short Optimized Chitosan-Based Nanoemulsion Improves Luteolin Release
title_sort optimized chitosan-based nanoemulsion improves luteolin release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301769/
https://www.ncbi.nlm.nih.gov/pubmed/37376041
http://dx.doi.org/10.3390/pharmaceutics15061592
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