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Deep-Learning Model of ResNet Combined with CBAM for Malignant–Benign Pulmonary Nodules Classification on Computed Tomography Images

Background and Objectives: Lung cancer remains a leading cause of cancer mortality worldwide. Accurately classifying benign pulmonary nodules and malignant ones is crucial for early diagnosis and improved patient outcomes. The purpose of this study is to explore the deep-learning model of ResNet com...

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Autores principales: Zhang, Yanfei, Feng, Wei, Wu, Zhiyuan, Li, Weiming, Tao, Lixin, Liu, Xiangtong, Zhang, Feng, Gao, Yan, Huang, Jian, Guo, Xiuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301795/
https://www.ncbi.nlm.nih.gov/pubmed/37374292
http://dx.doi.org/10.3390/medicina59061088
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author Zhang, Yanfei
Feng, Wei
Wu, Zhiyuan
Li, Weiming
Tao, Lixin
Liu, Xiangtong
Zhang, Feng
Gao, Yan
Huang, Jian
Guo, Xiuhua
author_facet Zhang, Yanfei
Feng, Wei
Wu, Zhiyuan
Li, Weiming
Tao, Lixin
Liu, Xiangtong
Zhang, Feng
Gao, Yan
Huang, Jian
Guo, Xiuhua
author_sort Zhang, Yanfei
collection PubMed
description Background and Objectives: Lung cancer remains a leading cause of cancer mortality worldwide. Accurately classifying benign pulmonary nodules and malignant ones is crucial for early diagnosis and improved patient outcomes. The purpose of this study is to explore the deep-learning model of ResNet combined with a convolutional block attention module (CBAM) for the differentiation between benign and malignant lung cancer, based on computed tomography (CT) images, morphological features, and clinical information. Methods and materials: In this study, 8241 CT slices containing pulmonary nodules were retrospectively included. A random sample comprising 20% (n = 1647) of the images was used as the test set, and the remaining data were used as the training set. ResNet combined CBAM (ResNet-CBAM) was used to establish classifiers on the basis of images, morphological features, and clinical information. Nonsubsampled dual-tree complex contourlet transform (NSDTCT) combined with SVM classifier (NSDTCT-SVM) was used as a comparative model. Results: The AUC and the accuracy of the CBAM-ResNet model were 0.940 and 0.867, respectively, in test set when there were only images as inputs. By combining the morphological features and clinical information, CBAM-ResNet shows better performance (AUC: 0.957, accuracy: 0.898). In comparison, a radiomic analysis using NSDTCT-SVM achieved AUC and accuracy values of 0.807 and 0.779, respectively. Conclusions: Our findings demonstrate that deep-learning models, combined with additional information, can enhance the classification performance of pulmonary nodules. This model can assist clinicians in accurately diagnosing pulmonary nodules in clinical practice.
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spelling pubmed-103017952023-06-29 Deep-Learning Model of ResNet Combined with CBAM for Malignant–Benign Pulmonary Nodules Classification on Computed Tomography Images Zhang, Yanfei Feng, Wei Wu, Zhiyuan Li, Weiming Tao, Lixin Liu, Xiangtong Zhang, Feng Gao, Yan Huang, Jian Guo, Xiuhua Medicina (Kaunas) Article Background and Objectives: Lung cancer remains a leading cause of cancer mortality worldwide. Accurately classifying benign pulmonary nodules and malignant ones is crucial for early diagnosis and improved patient outcomes. The purpose of this study is to explore the deep-learning model of ResNet combined with a convolutional block attention module (CBAM) for the differentiation between benign and malignant lung cancer, based on computed tomography (CT) images, morphological features, and clinical information. Methods and materials: In this study, 8241 CT slices containing pulmonary nodules were retrospectively included. A random sample comprising 20% (n = 1647) of the images was used as the test set, and the remaining data were used as the training set. ResNet combined CBAM (ResNet-CBAM) was used to establish classifiers on the basis of images, morphological features, and clinical information. Nonsubsampled dual-tree complex contourlet transform (NSDTCT) combined with SVM classifier (NSDTCT-SVM) was used as a comparative model. Results: The AUC and the accuracy of the CBAM-ResNet model were 0.940 and 0.867, respectively, in test set when there were only images as inputs. By combining the morphological features and clinical information, CBAM-ResNet shows better performance (AUC: 0.957, accuracy: 0.898). In comparison, a radiomic analysis using NSDTCT-SVM achieved AUC and accuracy values of 0.807 and 0.779, respectively. Conclusions: Our findings demonstrate that deep-learning models, combined with additional information, can enhance the classification performance of pulmonary nodules. This model can assist clinicians in accurately diagnosing pulmonary nodules in clinical practice. MDPI 2023-06-05 /pmc/articles/PMC10301795/ /pubmed/37374292 http://dx.doi.org/10.3390/medicina59061088 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Yanfei
Feng, Wei
Wu, Zhiyuan
Li, Weiming
Tao, Lixin
Liu, Xiangtong
Zhang, Feng
Gao, Yan
Huang, Jian
Guo, Xiuhua
Deep-Learning Model of ResNet Combined with CBAM for Malignant–Benign Pulmonary Nodules Classification on Computed Tomography Images
title Deep-Learning Model of ResNet Combined with CBAM for Malignant–Benign Pulmonary Nodules Classification on Computed Tomography Images
title_full Deep-Learning Model of ResNet Combined with CBAM for Malignant–Benign Pulmonary Nodules Classification on Computed Tomography Images
title_fullStr Deep-Learning Model of ResNet Combined with CBAM for Malignant–Benign Pulmonary Nodules Classification on Computed Tomography Images
title_full_unstemmed Deep-Learning Model of ResNet Combined with CBAM for Malignant–Benign Pulmonary Nodules Classification on Computed Tomography Images
title_short Deep-Learning Model of ResNet Combined with CBAM for Malignant–Benign Pulmonary Nodules Classification on Computed Tomography Images
title_sort deep-learning model of resnet combined with cbam for malignant–benign pulmonary nodules classification on computed tomography images
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301795/
https://www.ncbi.nlm.nih.gov/pubmed/37374292
http://dx.doi.org/10.3390/medicina59061088
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