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Chagas Disease: Medical and ECG Related Findings in an Indigenous Population in Colombia
Chagas Disease (CD) is highly prevalent among the indigenous populations in the Sierra Nevada de Santa Marta, Colombia. Villages examined show prevalence rates ranging from 43.6% up to 67.4%. In the present study, associated medical conditions were assessed with a particular focus on ECG alterations...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301814/ https://www.ncbi.nlm.nih.gov/pubmed/37368715 http://dx.doi.org/10.3390/tropicalmed8060297 |
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author | Kann, Simone Mendoza, Gustavo Andrés Concha Hartmann, Maria Frickmann, Hagen Kreienbrock, Lothar |
author_facet | Kann, Simone Mendoza, Gustavo Andrés Concha Hartmann, Maria Frickmann, Hagen Kreienbrock, Lothar |
author_sort | Kann, Simone |
collection | PubMed |
description | Chagas Disease (CD) is highly prevalent among the indigenous populations in the Sierra Nevada de Santa Marta, Colombia. Villages examined show prevalence rates ranging from 43.6% up to 67.4%. In the present study, associated medical conditions were assessed with a particular focus on ECG alterations. CD diagnosis was based on a rapid test, two different ELISAs, and a specific and highly sensitive Chagas real-time PCR. In both CD positive and CD negative patients, relations of the status and medical (physical examination-based, questionnaire-based) and/or electrocardiogram-based findings were investigated. As expected, CD-associated symptoms and complaints were predominantly found in CD-positive patients. Interestingly, ECG-findings were found to show the potential of leading to early CD diagnosis because ECG alterations were already seen in early stagechanges of the disease. In conclusion, although the observed ECG changes are unspecific, they should be considered as an indicator for a CD screening and, in case of positive results, an associated early treatment of the disease. |
format | Online Article Text |
id | pubmed-10301814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103018142023-06-29 Chagas Disease: Medical and ECG Related Findings in an Indigenous Population in Colombia Kann, Simone Mendoza, Gustavo Andrés Concha Hartmann, Maria Frickmann, Hagen Kreienbrock, Lothar Trop Med Infect Dis Article Chagas Disease (CD) is highly prevalent among the indigenous populations in the Sierra Nevada de Santa Marta, Colombia. Villages examined show prevalence rates ranging from 43.6% up to 67.4%. In the present study, associated medical conditions were assessed with a particular focus on ECG alterations. CD diagnosis was based on a rapid test, two different ELISAs, and a specific and highly sensitive Chagas real-time PCR. In both CD positive and CD negative patients, relations of the status and medical (physical examination-based, questionnaire-based) and/or electrocardiogram-based findings were investigated. As expected, CD-associated symptoms and complaints were predominantly found in CD-positive patients. Interestingly, ECG-findings were found to show the potential of leading to early CD diagnosis because ECG alterations were already seen in early stagechanges of the disease. In conclusion, although the observed ECG changes are unspecific, they should be considered as an indicator for a CD screening and, in case of positive results, an associated early treatment of the disease. MDPI 2023-05-29 /pmc/articles/PMC10301814/ /pubmed/37368715 http://dx.doi.org/10.3390/tropicalmed8060297 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kann, Simone Mendoza, Gustavo Andrés Concha Hartmann, Maria Frickmann, Hagen Kreienbrock, Lothar Chagas Disease: Medical and ECG Related Findings in an Indigenous Population in Colombia |
title | Chagas Disease: Medical and ECG Related Findings in an Indigenous Population in Colombia |
title_full | Chagas Disease: Medical and ECG Related Findings in an Indigenous Population in Colombia |
title_fullStr | Chagas Disease: Medical and ECG Related Findings in an Indigenous Population in Colombia |
title_full_unstemmed | Chagas Disease: Medical and ECG Related Findings in an Indigenous Population in Colombia |
title_short | Chagas Disease: Medical and ECG Related Findings in an Indigenous Population in Colombia |
title_sort | chagas disease: medical and ecg related findings in an indigenous population in colombia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301814/ https://www.ncbi.nlm.nih.gov/pubmed/37368715 http://dx.doi.org/10.3390/tropicalmed8060297 |
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