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Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance

Tumour progression and metastasis remain the leading causes of cancer-related death worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature surrounding tumours is not only a transport channel for nutrients, oxygen, and metabolites, but also a pathway for metastasis. There...

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Detalles Bibliográficos
Autores principales: Yao, Xinghong, Zeng, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301839/
https://www.ncbi.nlm.nih.gov/pubmed/37389120
http://dx.doi.org/10.3389/fphys.2023.1199225
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author Yao, Xinghong
Zeng, Ye
author_facet Yao, Xinghong
Zeng, Ye
author_sort Yao, Xinghong
collection PubMed
description Tumour progression and metastasis remain the leading causes of cancer-related death worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature surrounding tumours is not only a transport channel for nutrients, oxygen, and metabolites, but also a pathway for metastasis. There is a close interaction between tumour cells and endothelial cells in the tumour microenvironment. Recent studies have shown that tumour-associated endothelial cells have different characteristics from normal vascular endothelial cells, play an important role in tumour progression and metastasis, and are expected to be a key target for cancer therapy. This article reviews the tissue and cellular origin of tumour-associated endothelial cells and analyses the characteristics of tumour-associated endothelial cells. Finally, it summarises the role of tumour-associated endothelial cells in tumour progression and metastasis and the prospects for their use in clinical anti-angiogenic therapy.
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spelling pubmed-103018392023-06-29 Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance Yao, Xinghong Zeng, Ye Front Physiol Physiology Tumour progression and metastasis remain the leading causes of cancer-related death worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature surrounding tumours is not only a transport channel for nutrients, oxygen, and metabolites, but also a pathway for metastasis. There is a close interaction between tumour cells and endothelial cells in the tumour microenvironment. Recent studies have shown that tumour-associated endothelial cells have different characteristics from normal vascular endothelial cells, play an important role in tumour progression and metastasis, and are expected to be a key target for cancer therapy. This article reviews the tissue and cellular origin of tumour-associated endothelial cells and analyses the characteristics of tumour-associated endothelial cells. Finally, it summarises the role of tumour-associated endothelial cells in tumour progression and metastasis and the prospects for their use in clinical anti-angiogenic therapy. Frontiers Media S.A. 2023-06-14 /pmc/articles/PMC10301839/ /pubmed/37389120 http://dx.doi.org/10.3389/fphys.2023.1199225 Text en Copyright © 2023 Yao and Zeng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Yao, Xinghong
Zeng, Ye
Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
title Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
title_full Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
title_fullStr Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
title_full_unstemmed Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
title_short Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
title_sort tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301839/
https://www.ncbi.nlm.nih.gov/pubmed/37389120
http://dx.doi.org/10.3389/fphys.2023.1199225
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