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Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance
Tumour progression and metastasis remain the leading causes of cancer-related death worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature surrounding tumours is not only a transport channel for nutrients, oxygen, and metabolites, but also a pathway for metastasis. There...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301839/ https://www.ncbi.nlm.nih.gov/pubmed/37389120 http://dx.doi.org/10.3389/fphys.2023.1199225 |
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author | Yao, Xinghong Zeng, Ye |
author_facet | Yao, Xinghong Zeng, Ye |
author_sort | Yao, Xinghong |
collection | PubMed |
description | Tumour progression and metastasis remain the leading causes of cancer-related death worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature surrounding tumours is not only a transport channel for nutrients, oxygen, and metabolites, but also a pathway for metastasis. There is a close interaction between tumour cells and endothelial cells in the tumour microenvironment. Recent studies have shown that tumour-associated endothelial cells have different characteristics from normal vascular endothelial cells, play an important role in tumour progression and metastasis, and are expected to be a key target for cancer therapy. This article reviews the tissue and cellular origin of tumour-associated endothelial cells and analyses the characteristics of tumour-associated endothelial cells. Finally, it summarises the role of tumour-associated endothelial cells in tumour progression and metastasis and the prospects for their use in clinical anti-angiogenic therapy. |
format | Online Article Text |
id | pubmed-10301839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103018392023-06-29 Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance Yao, Xinghong Zeng, Ye Front Physiol Physiology Tumour progression and metastasis remain the leading causes of cancer-related death worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature surrounding tumours is not only a transport channel for nutrients, oxygen, and metabolites, but also a pathway for metastasis. There is a close interaction between tumour cells and endothelial cells in the tumour microenvironment. Recent studies have shown that tumour-associated endothelial cells have different characteristics from normal vascular endothelial cells, play an important role in tumour progression and metastasis, and are expected to be a key target for cancer therapy. This article reviews the tissue and cellular origin of tumour-associated endothelial cells and analyses the characteristics of tumour-associated endothelial cells. Finally, it summarises the role of tumour-associated endothelial cells in tumour progression and metastasis and the prospects for their use in clinical anti-angiogenic therapy. Frontiers Media S.A. 2023-06-14 /pmc/articles/PMC10301839/ /pubmed/37389120 http://dx.doi.org/10.3389/fphys.2023.1199225 Text en Copyright © 2023 Yao and Zeng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Yao, Xinghong Zeng, Ye Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance |
title | Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance |
title_full | Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance |
title_fullStr | Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance |
title_full_unstemmed | Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance |
title_short | Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance |
title_sort | tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301839/ https://www.ncbi.nlm.nih.gov/pubmed/37389120 http://dx.doi.org/10.3389/fphys.2023.1199225 |
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