Cargando…

Small Molecule Inhibitors as Therapeutic Agents Targeting Oncogenic Fusion Proteins: Current Status and Clinical

Oncogenic fusion proteins, arising from chromosomal rearrangements, have emerged as prominent drivers of tumorigenesis and crucial therapeutic targets in cancer research. In recent years, the potential of small molecular inhibitors in selectively targeting fusion proteins has exhibited significant p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Yichao, Jiang, Caihong, Wei, Guifeng, Sun, Kai, Wang, Ruijie, Qiu, Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301843/ https://www.ncbi.nlm.nih.gov/pubmed/37375228 http://dx.doi.org/10.3390/molecules28124672

Ejemplares similares

Small molecule inhibitors of RAS proteins with oncogenic mutations
por: Orgován, Zoltán, et al.
Publicado: (2020)

CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors
por: Dcona, M. Michael, et al.
Publicado: (2017)

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase
por: Moccia, Marialuisa, et al.
Publicado: (2015)

Small molecule inhibitors for cancer immunotherapy and associated biomarkers – the current status
por: Schlicher, Lisa, et al.
Publicado: (2023)

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers
por: Qiu, Luping, et al.
Publicado: (2018)

Current Status on Therapeutic Molecules Targeting Siglec Receptors
por: Lenza, María Pia, et al.
Publicado: (2020)

Small molecule KDM4s inhibitors as anti-cancer agents
por: Lin, Hongzhi, et al.
Publicado: (2018)

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
por: Chen, Bing-Jia, et al.
Publicado: (2014)

Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors—The Current Status
por: Beeraka, Narasimha M., et al.
Publicado: (2020)

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA
por: Velagapudi, Sai Pradeep, et al.
Publicado: (2017)

Cannabinoids as therapeutic agents in cancer: current status and future implications
por: Chakravarti, Bandana, et al.
Publicado: (2014)

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer
por: Weber, Helga, et al.
Publicado: (2017)

Targeting PELP1 oncogenic signaling in TNBC with the small molecule inhibitor SMIP34
por: Altwegg, Kristin A., et al.
Publicado: (2023)

Current Status of Poly(ADP-ribose) Polymerase Inhibitors as Novel Therapeutic Agents for Triple-Negative Breast Cancer
por: Hiller, David J., et al.
Publicado: (2012)

PARP inhibitors: current status and implications for anticancer therapeutics
por: Usmani, Hadi, et al.
Publicado: (2013)

ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1
por: Thai, M, et al.
Publicado: (2011)

Glycoengineering of Therapeutic Antibodies with Small Molecule Inhibitors
por: Li, Shasha, et al.
Publicado: (2021)

Development of Novel Therapeutic Agents by Inhibition of Oncogenic MicroRNAs
por: Nguyen, Dinh-Duc, et al.
Publicado: (2017)

Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors
por: Curreli, Francesca, et al.
Publicado: (2023)

Redox-Active Molecules as Therapeutic Agents
por: Fernandes, Ana Sofia
Publicado: (2022)

Small-Molecule Inhibitors Overcome Epigenetic Reprogramming for Cancer Therapy
por: Xiao, Wenjing, et al.
Publicado: (2021)

Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation
por: Ahmed, Muhammad Bilal, et al.
Publicado: (2022)

Indole-Based Small Molecules as Potential Therapeutic Agents for the Treatment of Fibrosis
por: Qin, Rui, et al.
Publicado: (2022)

Role of Histone Post-Translational Modifications in Inflammatory Diseases
por: Lin, Yingying, et al.
Publicado: (2022)

Small molecule inhibitors of osteoarthritis: Current development and future perspective
por: Liu, Dan, et al.
Publicado: (2023)

Small molecules as theranostic agents in cancer immunology
por: Li, Jindian, et al.
Publicado: (2019)

The new entries in the therapeutic armamentarium: The small molecule JAK inhibitors
por: Bechman, Katie, et al.
Publicado: (2019)

Editorial: Immunotherapy and small molecule inhibitors as combinational cancer therapeutics
por: Khan, Mohd Wajid Ali, et al.
Publicado: (2023)

Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication
por: Liu, Yanling, et al.
Publicado: (2023)

A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts
por: Huang, Fei, et al.
Publicado: (2014)

Novel Small-Molecule Inhibitor for the Oncogenic Tyrosine Phosphatase SHP2 with Anti-Breast Cancer Cell Effects
por: Hartman, Zachary, et al.
Publicado: (2020)

Small molecule tyrosine kinase inhibitors modulated blood immune cell counts in patients with oncogene-driven NSCLC
por: Ma, Weijie, et al.
Publicado: (2021)

The Small-Molecule E26-Transformation-Specific Inhibitor TK216 Attenuates the Oncogenic Properties of Pediatric Leukemia
por: Sharma, Ritul, et al.
Publicado: (2023)

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion
por: Chao, Luke H, et al.
Publicado: (2018)

Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers
por: Jiang, Tingting, et al.
Publicado: (2021)

Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors
por: Park, Seung Bum, et al.
Publicado: (2022)

Prospective Development of Small Molecule Targets to Oncogenic Ras Proteins
por: Chandrashekar, Reena, et al.
Publicado: (2013)

Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?—Current Status
por: Bulygin, Kirill V., et al.
Publicado: (2020)

Current Status of Multiple Drug Molecules, and Vaccines: An Update in SARS-CoV-2 Therapeutics
por: Kandimalla, Ramesh, et al.
Publicado: (2020)

Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent
por: Harikishore, Amaravadhi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_jj36mkkaa2e1djui9tmeq4bccp