Development and Evaluation of EDTA-Treated Rabbits for Bioavailability Study of Chelating Drugs Using Levofloxacin, Ciprofloxacin, Hemiacetal Ester Prodrugs, and Tetracycline

Laboratory rabbits are fed foods rich with cationic metals, and while fasting cannot empty gastric contents because of their coprophagic habits. This implies that, in rabbits, the oral bioavailability of chelating drugs could be modulated by the slow gastric emptying rates and the interaction (chela...

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Detalles Bibliográficos
Autores principales: Maeda, Yorinobu, Teraoka, Honoka, Okada, Ami, Yamamoto, Mirei, Natsuyama, Shintaro, Hieda, Yuhzo, Nagatsuka, Yuka, Sato, Yuhki, Goromaru, Takeshi, Murakami, Teruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301896/
https://www.ncbi.nlm.nih.gov/pubmed/37376038
http://dx.doi.org/10.3390/pharmaceutics15061589

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