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Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador
Human Papillomavirus (HPV) infection is associated with intraepithelial neoplasia and cervical cancer (CC). Ecuador has a high prevalence of cervical cancer, with more than 1600 new cases diagnosed annually. This study aimed to analyze oncogenes E6 and E7 of HPV16 in samples collected from women wit...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301947/ https://www.ncbi.nlm.nih.gov/pubmed/37376692 http://dx.doi.org/10.3390/v15061393 |
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author | Zhingre, Alicia Bedoya-Pilozo, César Gutiérrez-Pallo, Diana Badano, Inés Herrera-Yela, Andrés Salazar, Zoila Alarcón, Damaris Argüello-Bravo, Natali Espinoza, Maylen Ponce, Patricio Soto, Yudira Carrazco-Montalvo, Andrés |
author_facet | Zhingre, Alicia Bedoya-Pilozo, César Gutiérrez-Pallo, Diana Badano, Inés Herrera-Yela, Andrés Salazar, Zoila Alarcón, Damaris Argüello-Bravo, Natali Espinoza, Maylen Ponce, Patricio Soto, Yudira Carrazco-Montalvo, Andrés |
author_sort | Zhingre, Alicia |
collection | PubMed |
description | Human Papillomavirus (HPV) infection is associated with intraepithelial neoplasia and cervical cancer (CC). Ecuador has a high prevalence of cervical cancer, with more than 1600 new cases diagnosed annually. This study aimed to analyze oncogenes E6 and E7 of HPV16 in samples collected from women with cancerous and precancerous cervical lesions from the Ecuadorian coast. Twenty-nine women, including six with ASCUS, three with LSIL, thirteen with HSIL, and seven with Cacu, were analyzed. The most common SNPs were E6 350G or L83V (82.6%) and E6 145T/286A/289G/335T/350G or Q14H/F78Y/L83V (17.4%). Both variants are reported to be associated with an increased risk of cervical cancer in worldwide studies. In contrast, all E7 genes have conserved amino-acid positions. Phylogenetic trees showed the circulation of the D (26.1%) and A (73.9) lineages. The frequency of D was higher than that reported in other comparable studies in Ecuador and Latin America, and may be related to the ethnic composition of the studied populations. This study contributes to the characterization of the potential risk factors for cervical carcinogenesis associated with Ecuadorian women infected with HPV16. |
format | Online Article Text |
id | pubmed-10301947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103019472023-06-29 Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador Zhingre, Alicia Bedoya-Pilozo, César Gutiérrez-Pallo, Diana Badano, Inés Herrera-Yela, Andrés Salazar, Zoila Alarcón, Damaris Argüello-Bravo, Natali Espinoza, Maylen Ponce, Patricio Soto, Yudira Carrazco-Montalvo, Andrés Viruses Brief Report Human Papillomavirus (HPV) infection is associated with intraepithelial neoplasia and cervical cancer (CC). Ecuador has a high prevalence of cervical cancer, with more than 1600 new cases diagnosed annually. This study aimed to analyze oncogenes E6 and E7 of HPV16 in samples collected from women with cancerous and precancerous cervical lesions from the Ecuadorian coast. Twenty-nine women, including six with ASCUS, three with LSIL, thirteen with HSIL, and seven with Cacu, were analyzed. The most common SNPs were E6 350G or L83V (82.6%) and E6 145T/286A/289G/335T/350G or Q14H/F78Y/L83V (17.4%). Both variants are reported to be associated with an increased risk of cervical cancer in worldwide studies. In contrast, all E7 genes have conserved amino-acid positions. Phylogenetic trees showed the circulation of the D (26.1%) and A (73.9) lineages. The frequency of D was higher than that reported in other comparable studies in Ecuador and Latin America, and may be related to the ethnic composition of the studied populations. This study contributes to the characterization of the potential risk factors for cervical carcinogenesis associated with Ecuadorian women infected with HPV16. MDPI 2023-06-19 /pmc/articles/PMC10301947/ /pubmed/37376692 http://dx.doi.org/10.3390/v15061393 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Zhingre, Alicia Bedoya-Pilozo, César Gutiérrez-Pallo, Diana Badano, Inés Herrera-Yela, Andrés Salazar, Zoila Alarcón, Damaris Argüello-Bravo, Natali Espinoza, Maylen Ponce, Patricio Soto, Yudira Carrazco-Montalvo, Andrés Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title | Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_full | Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_fullStr | Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_full_unstemmed | Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_short | Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_sort | genetic variability in the e6/e7 region of human papillomavirus 16 in women from ecuador |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301947/ https://www.ncbi.nlm.nih.gov/pubmed/37376692 http://dx.doi.org/10.3390/v15061393 |
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