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The Residue and Dietary Risk Assessment of Spirotetramat and Its Four Metabolites in Cabbage Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry

Spirotetramat is a potential tetronic acid pesticide for controlling various pests with piercing–sucking mouthparts. To clarify its dietary risk on cabbage, we established an ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method and then investigated the residual...

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Autores principales: Cao, Junli, Li, Jindong, Ren, Pengcheng, Qi, Yanli, Qin, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302016/
https://www.ncbi.nlm.nih.gov/pubmed/37375316
http://dx.doi.org/10.3390/molecules28124763
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author Cao, Junli
Li, Jindong
Ren, Pengcheng
Qi, Yanli
Qin, Shu
author_facet Cao, Junli
Li, Jindong
Ren, Pengcheng
Qi, Yanli
Qin, Shu
author_sort Cao, Junli
collection PubMed
description Spirotetramat is a potential tetronic acid pesticide for controlling various pests with piercing–sucking mouthparts. To clarify its dietary risk on cabbage, we established an ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method and then investigated the residual levels of spirotetramat and its four metabolites in cabbage collected from field experiments under good agricultural practices (GAPs). The average recoveries of spirotetramat and its metabolites in cabbage were 74~110%, while the relative standard deviation (RSD) was 1~6%, and the limit of quantitation (LOQ) was 0.01 mg kg(−1). The terminal residue of spirotetramat was in the range of <0.05~0.33 mg kg(−1), the chronic dietary risk (RQ(c)) was 17.56%, and the acute dietary risk (RQ(a)) was 0.025~0.049%, which means an acceptable dietary intake risk. This study provides data to guide on the use of spirotetramat and to establish the maximum residue limits (MRLs) of spirotetramat on cabbage.
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spelling pubmed-103020162023-06-29 The Residue and Dietary Risk Assessment of Spirotetramat and Its Four Metabolites in Cabbage Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry Cao, Junli Li, Jindong Ren, Pengcheng Qi, Yanli Qin, Shu Molecules Article Spirotetramat is a potential tetronic acid pesticide for controlling various pests with piercing–sucking mouthparts. To clarify its dietary risk on cabbage, we established an ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method and then investigated the residual levels of spirotetramat and its four metabolites in cabbage collected from field experiments under good agricultural practices (GAPs). The average recoveries of spirotetramat and its metabolites in cabbage were 74~110%, while the relative standard deviation (RSD) was 1~6%, and the limit of quantitation (LOQ) was 0.01 mg kg(−1). The terminal residue of spirotetramat was in the range of <0.05~0.33 mg kg(−1), the chronic dietary risk (RQ(c)) was 17.56%, and the acute dietary risk (RQ(a)) was 0.025~0.049%, which means an acceptable dietary intake risk. This study provides data to guide on the use of spirotetramat and to establish the maximum residue limits (MRLs) of spirotetramat on cabbage. MDPI 2023-06-14 /pmc/articles/PMC10302016/ /pubmed/37375316 http://dx.doi.org/10.3390/molecules28124763 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cao, Junli
Li, Jindong
Ren, Pengcheng
Qi, Yanli
Qin, Shu
The Residue and Dietary Risk Assessment of Spirotetramat and Its Four Metabolites in Cabbage Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
title The Residue and Dietary Risk Assessment of Spirotetramat and Its Four Metabolites in Cabbage Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
title_full The Residue and Dietary Risk Assessment of Spirotetramat and Its Four Metabolites in Cabbage Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
title_fullStr The Residue and Dietary Risk Assessment of Spirotetramat and Its Four Metabolites in Cabbage Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
title_full_unstemmed The Residue and Dietary Risk Assessment of Spirotetramat and Its Four Metabolites in Cabbage Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
title_short The Residue and Dietary Risk Assessment of Spirotetramat and Its Four Metabolites in Cabbage Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry
title_sort residue and dietary risk assessment of spirotetramat and its four metabolites in cabbage using ultra-high-performance liquid chromatography–tandem mass spectrometry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302016/
https://www.ncbi.nlm.nih.gov/pubmed/37375316
http://dx.doi.org/10.3390/molecules28124763
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