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DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond

We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received authorization for use. DNA vaccines have signific...

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Autores principales: Maslow, Joel N., Kwon, Ijoo, Kudchodkar, Sagar B., Kane, Deborah, Tadesse, Amha, Lee, Hyojin, Park, Young K., Muthumani, Kar, Roberts, Christine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302025/
https://www.ncbi.nlm.nih.gov/pubmed/37376404
http://dx.doi.org/10.3390/vaccines11061016
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author Maslow, Joel N.
Kwon, Ijoo
Kudchodkar, Sagar B.
Kane, Deborah
Tadesse, Amha
Lee, Hyojin
Park, Young K.
Muthumani, Kar
Roberts, Christine C.
author_facet Maslow, Joel N.
Kwon, Ijoo
Kudchodkar, Sagar B.
Kane, Deborah
Tadesse, Amha
Lee, Hyojin
Park, Young K.
Muthumani, Kar
Roberts, Christine C.
author_sort Maslow, Joel N.
collection PubMed
description We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received authorization for use. DNA vaccines have significant advantages with regard to the rapidity of production, thermostability, safety profile, and cellular immune responses. Based on user needs and cost, we compare the three devices used in the SARS-CoV-2 clinical trials. Of the three devices, the GeneDerm suction device offers numerous benefits, particularly for international vaccination campaigns. As such, DNA vaccines represent a promising option for future pandemics.
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spelling pubmed-103020252023-06-29 DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond Maslow, Joel N. Kwon, Ijoo Kudchodkar, Sagar B. Kane, Deborah Tadesse, Amha Lee, Hyojin Park, Young K. Muthumani, Kar Roberts, Christine C. Vaccines (Basel) Article We highlight the significant progress in developing DNA vaccines during the SARS-CoV-2 pandemic. Specifically, we provide a comprehensive review of the DNA vaccines that have progressed to Phase 2 testing or beyond, including those that have received authorization for use. DNA vaccines have significant advantages with regard to the rapidity of production, thermostability, safety profile, and cellular immune responses. Based on user needs and cost, we compare the three devices used in the SARS-CoV-2 clinical trials. Of the three devices, the GeneDerm suction device offers numerous benefits, particularly for international vaccination campaigns. As such, DNA vaccines represent a promising option for future pandemics. MDPI 2023-05-23 /pmc/articles/PMC10302025/ /pubmed/37376404 http://dx.doi.org/10.3390/vaccines11061016 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maslow, Joel N.
Kwon, Ijoo
Kudchodkar, Sagar B.
Kane, Deborah
Tadesse, Amha
Lee, Hyojin
Park, Young K.
Muthumani, Kar
Roberts, Christine C.
DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond
title DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond
title_full DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond
title_fullStr DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond
title_full_unstemmed DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond
title_short DNA Vaccines for Epidemic Preparedness: SARS-CoV-2 and Beyond
title_sort dna vaccines for epidemic preparedness: sars-cov-2 and beyond
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302025/
https://www.ncbi.nlm.nih.gov/pubmed/37376404
http://dx.doi.org/10.3390/vaccines11061016
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