Cargando…
Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives
Neural tissue engineering presents a compelling technological breakthrough in restoring brain function, holding immense promise. However, the quest to develop implantable scaffolds for neural culture that fulfill all necessary criteria poses a remarkable challenge for material science. These materia...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302050/ https://www.ncbi.nlm.nih.gov/pubmed/37376198 http://dx.doi.org/10.3390/pharmaceutics15061750 |
_version_ | 1785064957630480384 |
---|---|
author | Villanueva-Flores, Francisca Garcia-Atutxa, Igor Santos, Arturo Armendariz-Borunda, Juan |
author_facet | Villanueva-Flores, Francisca Garcia-Atutxa, Igor Santos, Arturo Armendariz-Borunda, Juan |
author_sort | Villanueva-Flores, Francisca |
collection | PubMed |
description | Neural tissue engineering presents a compelling technological breakthrough in restoring brain function, holding immense promise. However, the quest to develop implantable scaffolds for neural culture that fulfill all necessary criteria poses a remarkable challenge for material science. These materials must possess a host of desirable characteristics, including support for cellular survival, proliferation, and neuronal migration and the minimization of inflammatory responses. Moreover, they should facilitate electrochemical cell communication, display mechanical properties akin to the brain, emulate the intricate architecture of the extracellular matrix, and ideally allow the controlled release of substances. This comprehensive review delves into the primary requisites, limitations, and prospective avenues for scaffold design in brain tissue engineering. By offering a panoramic overview, our work aims to serve as an essential resource, guiding the creation of materials endowed with bio-mimetic properties, ultimately revolutionizing the treatment of neurological disorders by developing brain-implantable scaffolds. |
format | Online Article Text |
id | pubmed-10302050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103020502023-06-29 Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives Villanueva-Flores, Francisca Garcia-Atutxa, Igor Santos, Arturo Armendariz-Borunda, Juan Pharmaceutics Review Neural tissue engineering presents a compelling technological breakthrough in restoring brain function, holding immense promise. However, the quest to develop implantable scaffolds for neural culture that fulfill all necessary criteria poses a remarkable challenge for material science. These materials must possess a host of desirable characteristics, including support for cellular survival, proliferation, and neuronal migration and the minimization of inflammatory responses. Moreover, they should facilitate electrochemical cell communication, display mechanical properties akin to the brain, emulate the intricate architecture of the extracellular matrix, and ideally allow the controlled release of substances. This comprehensive review delves into the primary requisites, limitations, and prospective avenues for scaffold design in brain tissue engineering. By offering a panoramic overview, our work aims to serve as an essential resource, guiding the creation of materials endowed with bio-mimetic properties, ultimately revolutionizing the treatment of neurological disorders by developing brain-implantable scaffolds. MDPI 2023-06-16 /pmc/articles/PMC10302050/ /pubmed/37376198 http://dx.doi.org/10.3390/pharmaceutics15061750 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Villanueva-Flores, Francisca Garcia-Atutxa, Igor Santos, Arturo Armendariz-Borunda, Juan Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives |
title | Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives |
title_full | Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives |
title_fullStr | Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives |
title_full_unstemmed | Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives |
title_short | Toward a New Generation of Bio-Scaffolds for Neural Tissue Engineering: Challenges and Perspectives |
title_sort | toward a new generation of bio-scaffolds for neural tissue engineering: challenges and perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302050/ https://www.ncbi.nlm.nih.gov/pubmed/37376198 http://dx.doi.org/10.3390/pharmaceutics15061750 |
work_keys_str_mv | AT villanuevafloresfrancisca towardanewgenerationofbioscaffoldsforneuraltissueengineeringchallengesandperspectives AT garciaatutxaigor towardanewgenerationofbioscaffoldsforneuraltissueengineeringchallengesandperspectives AT santosarturo towardanewgenerationofbioscaffoldsforneuraltissueengineeringchallengesandperspectives AT armendarizborundajuan towardanewgenerationofbioscaffoldsforneuraltissueengineeringchallengesandperspectives |