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Phenylalanine Residues in the Active Site of CYP2E1 Participate in Determining the Binding Orientation and Metabolism-Dependent Genotoxicity of Aromatic Compounds

The composition of amino acids forming the active site of a CYP enzyme is impactful in its substrate selectivity. For CYP2E1, the role of PHE residues in the formation of effective binding orientations for its aromatic substrates remains unclear. In this study, molecular docking and molecular dynami...

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Detalles Bibliográficos
Autores principales:	Hu, Keqi, Tu, Hongwei, Xie, Jiayi, Yang, Zongying, Li, Zihuan, Chen, Yijing, Liu, Yungang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302094/ https://www.ncbi.nlm.nih.gov/pubmed/37368596 http://dx.doi.org/10.3390/toxics11060495

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