Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions

Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik–Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free conditions. The nucleophilic substitution reaction of...

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Autores principales: Souii, Ichrak, Sanhoury, Med Abderrahmane, Vicario, Javier, Jiménez-Aberásturi, Xabier, Efrit, Mohamed L., M’rabet, Hedi, de los Santos, Jesús M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302223/
https://www.ncbi.nlm.nih.gov/pubmed/37375233
http://dx.doi.org/10.3390/molecules28124678
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author Souii, Ichrak
Sanhoury, Med Abderrahmane
Vicario, Javier
Jiménez-Aberásturi, Xabier
Efrit, Mohamed L.
M’rabet, Hedi
de los Santos, Jesús M.
author_facet Souii, Ichrak
Sanhoury, Med Abderrahmane
Vicario, Javier
Jiménez-Aberásturi, Xabier
Efrit, Mohamed L.
M’rabet, Hedi
de los Santos, Jesús M.
author_sort Souii, Ichrak
collection PubMed
description Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik–Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free conditions. The nucleophilic substitution reaction of bis(α-aminophosphonates) prepared and ethyl (2-bromomethyl)acrylate under mild reaction conditions afforded an original synthetic approach to a new series of bis(allylic-α-aminophosphonates).
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spelling pubmed-103022232023-06-29 Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions Souii, Ichrak Sanhoury, Med Abderrahmane Vicario, Javier Jiménez-Aberásturi, Xabier Efrit, Mohamed L. M’rabet, Hedi de los Santos, Jesús M. Molecules Article Several bis(α-aminophosphonates) have been conveniently prepared in good yields using a straightforward multicomponent Kabachnik–Fields reaction between ethane 1,2-diamine or propane 1,3-diamine, diethylphosphite and aldehydes under catalyst-free conditions. The nucleophilic substitution reaction of bis(α-aminophosphonates) prepared and ethyl (2-bromomethyl)acrylate under mild reaction conditions afforded an original synthetic approach to a new series of bis(allylic-α-aminophosphonates). MDPI 2023-06-09 /pmc/articles/PMC10302223/ /pubmed/37375233 http://dx.doi.org/10.3390/molecules28124678 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Souii, Ichrak
Sanhoury, Med Abderrahmane
Vicario, Javier
Jiménez-Aberásturi, Xabier
Efrit, Mohamed L.
M’rabet, Hedi
de los Santos, Jesús M.
Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions
title Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions
title_full Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions
title_fullStr Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions
title_full_unstemmed Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions
title_short Synthesis and Characterization of a New Series of Bis(allylic-α-aminophosphonates) under Mild Reaction Conditions
title_sort synthesis and characterization of a new series of bis(allylic-α-aminophosphonates) under mild reaction conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302223/
https://www.ncbi.nlm.nih.gov/pubmed/37375233
http://dx.doi.org/10.3390/molecules28124678
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