Crotamine/siRNA Nanocomplexes for Functional Downregulation of Syndecan-1 in Renal Proximal Tubular Epithelial Cells

Proteinuria drives progressive tubulointerstitial fibrosis in native and transplanted kidneys, mainly through the activation of proximal tubular epithelial cells (PTECs). During proteinuria, PTEC syndecan-1 functions as a docking platform for properdin-mediated alternative complement activation. Non...

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Detalles Bibliográficos
Autores principales: Campeiro, Joana D’Arc, Dam, Wendy A., Hayashi, Mirian A. F., van den Born, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302291/
https://www.ncbi.nlm.nih.gov/pubmed/37376025
http://dx.doi.org/10.3390/pharmaceutics15061576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302291/
https://www.ncbi.nlm.nih.gov/pubmed/37376025
http://dx.doi.org/10.3390/pharmaceutics15061576

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