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Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status

The anthropogenic environment and diet introduce many metals into the human body, both essential and toxic. Absorption leads to systemic exposure and accumulation in body fluids and tissues. Both excess and deficiency of trace elements are health hazards. The primary aim of the present study was to...

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Autores principales: Baj, Jacek, Kowalska, Beata, Flieger, Wojciech, Radzikowska-Büchner, Elżbieta, Forma, Alicja, Czeczelewski, Marcin, Kędzierawski, Paweł, Karakuła, Kaja, Flieger, Michał, Majerek, Dariusz, Teresiński, Grzegorz, Maciejewski, Ryszard, Flieger, Jolanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302479/
https://www.ncbi.nlm.nih.gov/pubmed/37375704
http://dx.doi.org/10.3390/nu15122799
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author Baj, Jacek
Kowalska, Beata
Flieger, Wojciech
Radzikowska-Büchner, Elżbieta
Forma, Alicja
Czeczelewski, Marcin
Kędzierawski, Paweł
Karakuła, Kaja
Flieger, Michał
Majerek, Dariusz
Teresiński, Grzegorz
Maciejewski, Ryszard
Flieger, Jolanta
author_facet Baj, Jacek
Kowalska, Beata
Flieger, Wojciech
Radzikowska-Büchner, Elżbieta
Forma, Alicja
Czeczelewski, Marcin
Kędzierawski, Paweł
Karakuła, Kaja
Flieger, Michał
Majerek, Dariusz
Teresiński, Grzegorz
Maciejewski, Ryszard
Flieger, Jolanta
author_sort Baj, Jacek
collection PubMed
description The anthropogenic environment and diet introduce many metals into the human body, both essential and toxic. Absorption leads to systemic exposure and accumulation in body fluids and tissues. Both excess and deficiency of trace elements are health hazards. The primary aim of the present study was to evaluate the concentration of 51 elements in liver samples and 11 selected brain regions obtained at post-mortem examination from a population of adults living in south-eastern Poland (n = 15). A total of 180 analyses were performed by inductively coupled plasma mass spectrometry in two independent replicates. The collected data show very high individual variability in the content of the investigated elements. Macroelements such as sodium, magnesium, phosphorus, potassium, calcium, iron, and zinc occurred in the highest concentrations and with the greatest statistically significant variations. Although the elemental content of the brain and liver differed significantly, the strongest positive correlation between liver and polus frontalis was observed for the essential element selenium (0.9338) and the strongest negative one for manganese (−0.4316) and lanthanum (−0.5110). The brain areas studied have different requirements for phosphorus, manganese, iron, and molybdenum. In addition, males had a significantly (p < 0.05) higher brain content of lanthanides and actinides than females. The results of this study show that the inhabitants of south-eastern Poland are exposed to a fairly uniform accumulation of aluminum and vanadium in the brain, which have the highest affinity to the thalamus dorsalis. This result proves that there is environmental exposure to these elements.
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spelling pubmed-103024792023-06-29 Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status Baj, Jacek Kowalska, Beata Flieger, Wojciech Radzikowska-Büchner, Elżbieta Forma, Alicja Czeczelewski, Marcin Kędzierawski, Paweł Karakuła, Kaja Flieger, Michał Majerek, Dariusz Teresiński, Grzegorz Maciejewski, Ryszard Flieger, Jolanta Nutrients Article The anthropogenic environment and diet introduce many metals into the human body, both essential and toxic. Absorption leads to systemic exposure and accumulation in body fluids and tissues. Both excess and deficiency of trace elements are health hazards. The primary aim of the present study was to evaluate the concentration of 51 elements in liver samples and 11 selected brain regions obtained at post-mortem examination from a population of adults living in south-eastern Poland (n = 15). A total of 180 analyses were performed by inductively coupled plasma mass spectrometry in two independent replicates. The collected data show very high individual variability in the content of the investigated elements. Macroelements such as sodium, magnesium, phosphorus, potassium, calcium, iron, and zinc occurred in the highest concentrations and with the greatest statistically significant variations. Although the elemental content of the brain and liver differed significantly, the strongest positive correlation between liver and polus frontalis was observed for the essential element selenium (0.9338) and the strongest negative one for manganese (−0.4316) and lanthanum (−0.5110). The brain areas studied have different requirements for phosphorus, manganese, iron, and molybdenum. In addition, males had a significantly (p < 0.05) higher brain content of lanthanides and actinides than females. The results of this study show that the inhabitants of south-eastern Poland are exposed to a fairly uniform accumulation of aluminum and vanadium in the brain, which have the highest affinity to the thalamus dorsalis. This result proves that there is environmental exposure to these elements. MDPI 2023-06-19 /pmc/articles/PMC10302479/ /pubmed/37375704 http://dx.doi.org/10.3390/nu15122799 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baj, Jacek
Kowalska, Beata
Flieger, Wojciech
Radzikowska-Büchner, Elżbieta
Forma, Alicja
Czeczelewski, Marcin
Kędzierawski, Paweł
Karakuła, Kaja
Flieger, Michał
Majerek, Dariusz
Teresiński, Grzegorz
Maciejewski, Ryszard
Flieger, Jolanta
Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status
title Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status
title_full Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status
title_fullStr Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status
title_full_unstemmed Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status
title_short Assessment of the Concentration of 51 Elements in the Liver and in Various Parts of the Human Brain—Profiling of the Mineral Status
title_sort assessment of the concentration of 51 elements in the liver and in various parts of the human brain—profiling of the mineral status
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302479/
https://www.ncbi.nlm.nih.gov/pubmed/37375704
http://dx.doi.org/10.3390/nu15122799
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