Cargando…
Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2
This study assesses the circulation of human respiratory syncytial virus (HRSV) genotypes before, during, and toward the end of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in children and determines the influence of the pandemic on HRSV circulation patterns and evolutio...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302487/ https://www.ncbi.nlm.nih.gov/pubmed/37376518 http://dx.doi.org/10.3390/v15061218 |
_version_ | 1785065056335036416 |
---|---|
author | Virant, Monika Jevšnik Luštrek, Manca Kogoj, Rok Petrovec, Miroslav Uršič, Tina |
author_facet | Virant, Monika Jevšnik Luštrek, Manca Kogoj, Rok Petrovec, Miroslav Uršič, Tina |
author_sort | Virant, Monika Jevšnik |
collection | PubMed |
description | This study assesses the circulation of human respiratory syncytial virus (HRSV) genotypes before, during, and toward the end of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in children and determines the influence of the pandemic on HRSV circulation patterns and evolution. Phylogenetic analysis of the hypervariable glycoprotein G gene was performed on 221/261 (84.7%) HRSV-positive samples and shows two separated clusters, one belonging to HRSV-A (129/221) and another to HRSV-B (92/221). All Slovenian HRSV-A strains contained the 72-nucleotide-long duplicated region in the attachment glycoprotein G gene and were classified as lineage GA2.3.5. All Slovenian HRSV-B strains similarly contained a 60-nucleotide-long duplicated region in the attachment glycoprotein G gene and were classified as lineage GB5.0.5a. During the 3-year period (2018–2021) covered by the study, no significant differences were observed within strains detected before the SARS-CoV-2 pandemic, during it, and after the implementation of nonpharmaceutical preventive measures. Slovenian HRSV-A strains seem to be more diverse than HRSV-B strains. Therefore, further whole-genome investigations would be required for better monitoring of the long-term impact of SARS-CoV-2 endemic circulation and the formation of new HRSV lineages and epidemiological patterns. |
format | Online Article Text |
id | pubmed-10302487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103024872023-06-29 Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2 Virant, Monika Jevšnik Luštrek, Manca Kogoj, Rok Petrovec, Miroslav Uršič, Tina Viruses Article This study assesses the circulation of human respiratory syncytial virus (HRSV) genotypes before, during, and toward the end of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in children and determines the influence of the pandemic on HRSV circulation patterns and evolution. Phylogenetic analysis of the hypervariable glycoprotein G gene was performed on 221/261 (84.7%) HRSV-positive samples and shows two separated clusters, one belonging to HRSV-A (129/221) and another to HRSV-B (92/221). All Slovenian HRSV-A strains contained the 72-nucleotide-long duplicated region in the attachment glycoprotein G gene and were classified as lineage GA2.3.5. All Slovenian HRSV-B strains similarly contained a 60-nucleotide-long duplicated region in the attachment glycoprotein G gene and were classified as lineage GB5.0.5a. During the 3-year period (2018–2021) covered by the study, no significant differences were observed within strains detected before the SARS-CoV-2 pandemic, during it, and after the implementation of nonpharmaceutical preventive measures. Slovenian HRSV-A strains seem to be more diverse than HRSV-B strains. Therefore, further whole-genome investigations would be required for better monitoring of the long-term impact of SARS-CoV-2 endemic circulation and the formation of new HRSV lineages and epidemiological patterns. MDPI 2023-05-23 /pmc/articles/PMC10302487/ /pubmed/37376518 http://dx.doi.org/10.3390/v15061218 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Virant, Monika Jevšnik Luštrek, Manca Kogoj, Rok Petrovec, Miroslav Uršič, Tina Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2 |
title | Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2 |
title_full | Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2 |
title_fullStr | Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2 |
title_full_unstemmed | Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2 |
title_short | Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2 |
title_sort | changes in hrsv epidemiology but not circulating variants in hospitalized children due to the emergence of sars-cov-2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302487/ https://www.ncbi.nlm.nih.gov/pubmed/37376518 http://dx.doi.org/10.3390/v15061218 |
work_keys_str_mv | AT virantmonikajevsnik changesinhrsvepidemiologybutnotcirculatingvariantsinhospitalizedchildrenduetotheemergenceofsarscov2 AT lustrekmanca changesinhrsvepidemiologybutnotcirculatingvariantsinhospitalizedchildrenduetotheemergenceofsarscov2 AT kogojrok changesinhrsvepidemiologybutnotcirculatingvariantsinhospitalizedchildrenduetotheemergenceofsarscov2 AT petrovecmiroslav changesinhrsvepidemiologybutnotcirculatingvariantsinhospitalizedchildrenduetotheemergenceofsarscov2 AT ursictina changesinhrsvepidemiologybutnotcirculatingvariantsinhospitalizedchildrenduetotheemergenceofsarscov2 |