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Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention
Vitamin D plays a vital role in regulating calcium and phosphate metabolism and maintaining bone health. A state of prolonged or profound vitamin D deficiency (VDD) can result in rickets in children and osteomalacia in children and adults. Recent studies have demonstrated the pleiotropic action of v...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302516/ https://www.ncbi.nlm.nih.gov/pubmed/37375708 http://dx.doi.org/10.3390/nu15122805 |
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author | Joshi, Madhura Uday, Suma |
author_facet | Joshi, Madhura Uday, Suma |
author_sort | Joshi, Madhura |
collection | PubMed |
description | Vitamin D plays a vital role in regulating calcium and phosphate metabolism and maintaining bone health. A state of prolonged or profound vitamin D deficiency (VDD) can result in rickets in children and osteomalacia in children and adults. Recent studies have demonstrated the pleiotropic action of vitamin D and identified its effects on multiple biological processes in addition to bone health. VDD is more prevalent in chronic childhood conditions such as long-standing systemic illnesses affecting the renal, liver, gastrointestinal, skin, neurologic and musculoskeletal systems. VDD superimposed on the underlying disease process and treatments that can adversely affect bone turnover can all add to the disease burden in these groups of children. The current review outlines the causes and mechanisms underlying poor bone health in certain groups of children and young people with chronic diseases with an emphasis on the proactive screening and treatment of VDD. |
format | Online Article Text |
id | pubmed-10302516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103025162023-06-29 Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention Joshi, Madhura Uday, Suma Nutrients Review Vitamin D plays a vital role in regulating calcium and phosphate metabolism and maintaining bone health. A state of prolonged or profound vitamin D deficiency (VDD) can result in rickets in children and osteomalacia in children and adults. Recent studies have demonstrated the pleiotropic action of vitamin D and identified its effects on multiple biological processes in addition to bone health. VDD is more prevalent in chronic childhood conditions such as long-standing systemic illnesses affecting the renal, liver, gastrointestinal, skin, neurologic and musculoskeletal systems. VDD superimposed on the underlying disease process and treatments that can adversely affect bone turnover can all add to the disease burden in these groups of children. The current review outlines the causes and mechanisms underlying poor bone health in certain groups of children and young people with chronic diseases with an emphasis on the proactive screening and treatment of VDD. MDPI 2023-06-19 /pmc/articles/PMC10302516/ /pubmed/37375708 http://dx.doi.org/10.3390/nu15122805 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Joshi, Madhura Uday, Suma Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention |
title | Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention |
title_full | Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention |
title_fullStr | Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention |
title_full_unstemmed | Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention |
title_short | Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention |
title_sort | vitamin d deficiency in chronic childhood disorders: importance of screening and prevention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302516/ https://www.ncbi.nlm.nih.gov/pubmed/37375708 http://dx.doi.org/10.3390/nu15122805 |
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