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NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances
The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and development by enhancing cell proliferation, invasion, and metastasis, preventing cell death, facilitating angiogenesis, reg...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302521/ https://www.ncbi.nlm.nih.gov/pubmed/37375731 http://dx.doi.org/10.3390/ph16060783 |
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author | Wu, Xuesong Sun, Liang Xu, Fangying |
author_facet | Wu, Xuesong Sun, Liang Xu, Fangying |
author_sort | Wu, Xuesong |
collection | PubMed |
description | The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and development by enhancing cell proliferation, invasion, and metastasis, preventing cell death, facilitating angiogenesis, regulating tumor immune microenvironment and metabolism, and inducing therapeutic resistance. Notably, NF-κB functions as a double-edged sword exerting positive or negative influences on cancers. In this review, we summarize and discuss recent research on the regulation of NF-κB in cancer cell deaths, therapy resistance, and NF-κB-based nano delivery systems. |
format | Online Article Text |
id | pubmed-10302521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103025212023-06-29 NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances Wu, Xuesong Sun, Liang Xu, Fangying Pharmaceuticals (Basel) Review The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and development by enhancing cell proliferation, invasion, and metastasis, preventing cell death, facilitating angiogenesis, regulating tumor immune microenvironment and metabolism, and inducing therapeutic resistance. Notably, NF-κB functions as a double-edged sword exerting positive or negative influences on cancers. In this review, we summarize and discuss recent research on the regulation of NF-κB in cancer cell deaths, therapy resistance, and NF-κB-based nano delivery systems. MDPI 2023-05-24 /pmc/articles/PMC10302521/ /pubmed/37375731 http://dx.doi.org/10.3390/ph16060783 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wu, Xuesong Sun, Liang Xu, Fangying NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances |
title | NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances |
title_full | NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances |
title_fullStr | NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances |
title_full_unstemmed | NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances |
title_short | NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances |
title_sort | nf-κb in cell deaths, therapeutic resistance and nanotherapy of tumors: recent advances |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302521/ https://www.ncbi.nlm.nih.gov/pubmed/37375731 http://dx.doi.org/10.3390/ph16060783 |
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