Cargando…

NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances

The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and development by enhancing cell proliferation, invasion, and metastasis, preventing cell death, facilitating angiogenesis, reg...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Xuesong, Sun, Liang, Xu, Fangying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302521/
https://www.ncbi.nlm.nih.gov/pubmed/37375731
http://dx.doi.org/10.3390/ph16060783
_version_ 1785065064160559104
author Wu, Xuesong
Sun, Liang
Xu, Fangying
author_facet Wu, Xuesong
Sun, Liang
Xu, Fangying
author_sort Wu, Xuesong
collection PubMed
description The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and development by enhancing cell proliferation, invasion, and metastasis, preventing cell death, facilitating angiogenesis, regulating tumor immune microenvironment and metabolism, and inducing therapeutic resistance. Notably, NF-κB functions as a double-edged sword exerting positive or negative influences on cancers. In this review, we summarize and discuss recent research on the regulation of NF-κB in cancer cell deaths, therapy resistance, and NF-κB-based nano delivery systems.
format Online
Article
Text
id pubmed-10302521
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103025212023-06-29 NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances Wu, Xuesong Sun, Liang Xu, Fangying Pharmaceuticals (Basel) Review The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and development by enhancing cell proliferation, invasion, and metastasis, preventing cell death, facilitating angiogenesis, regulating tumor immune microenvironment and metabolism, and inducing therapeutic resistance. Notably, NF-κB functions as a double-edged sword exerting positive or negative influences on cancers. In this review, we summarize and discuss recent research on the regulation of NF-κB in cancer cell deaths, therapy resistance, and NF-κB-based nano delivery systems. MDPI 2023-05-24 /pmc/articles/PMC10302521/ /pubmed/37375731 http://dx.doi.org/10.3390/ph16060783 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Xuesong
Sun, Liang
Xu, Fangying
NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances
title NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances
title_full NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances
title_fullStr NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances
title_full_unstemmed NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances
title_short NF-κB in Cell Deaths, Therapeutic Resistance and Nanotherapy of Tumors: Recent Advances
title_sort nf-κb in cell deaths, therapeutic resistance and nanotherapy of tumors: recent advances
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302521/
https://www.ncbi.nlm.nih.gov/pubmed/37375731
http://dx.doi.org/10.3390/ph16060783
work_keys_str_mv AT wuxuesong nfkbincelldeathstherapeuticresistanceandnanotherapyoftumorsrecentadvances
AT sunliang nfkbincelldeathstherapeuticresistanceandnanotherapyoftumorsrecentadvances
AT xufangying nfkbincelldeathstherapeuticresistanceandnanotherapyoftumorsrecentadvances