Current and emerging applications of liquid biopsy in pan-cancer
Cancer morbidity and mortality are growing rapidly worldwide and it is urgent to develop a convenient and effective method that can identify cancer patients at an early stage and predict treatment outcomes. As a minimally invasive and reproducible tool, liquid biopsy (LB) offers the opportunity to d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302532/ https://www.ncbi.nlm.nih.gov/pubmed/37315508 http://dx.doi.org/10.1016/j.tranon.2023.101720 |
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author | Wang, Wenxiang He, Yue Yang, Fan Chen, Kezhong |
author_facet | Wang, Wenxiang He, Yue Yang, Fan Chen, Kezhong |
author_sort | Wang, Wenxiang |
collection | PubMed |
description | Cancer morbidity and mortality are growing rapidly worldwide and it is urgent to develop a convenient and effective method that can identify cancer patients at an early stage and predict treatment outcomes. As a minimally invasive and reproducible tool, liquid biopsy (LB) offers the opportunity to detect, analyze and monitor cancer in any body fluids including blood, complementing the limitations of tissue biopsy. In liquid biopsy, circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are the two most common biomarkers, displaying great potential in the clinical application of pan-cancer. In this review, we expound the samples, targets, and newest techniques in liquid biopsy and summarize current clinical applications in several specific cancers. Besides, we put forward a bright prospect for further exploring the emerging application of liquid biopsy in the field of pan-cancer precision medicine. |
format | Online Article Text |
id | pubmed-10302532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Neoplasia Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103025322023-06-29 Current and emerging applications of liquid biopsy in pan-cancer Wang, Wenxiang He, Yue Yang, Fan Chen, Kezhong Transl Oncol Commentary Cancer morbidity and mortality are growing rapidly worldwide and it is urgent to develop a convenient and effective method that can identify cancer patients at an early stage and predict treatment outcomes. As a minimally invasive and reproducible tool, liquid biopsy (LB) offers the opportunity to detect, analyze and monitor cancer in any body fluids including blood, complementing the limitations of tissue biopsy. In liquid biopsy, circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are the two most common biomarkers, displaying great potential in the clinical application of pan-cancer. In this review, we expound the samples, targets, and newest techniques in liquid biopsy and summarize current clinical applications in several specific cancers. Besides, we put forward a bright prospect for further exploring the emerging application of liquid biopsy in the field of pan-cancer precision medicine. Neoplasia Press 2023-06-12 /pmc/articles/PMC10302532/ /pubmed/37315508 http://dx.doi.org/10.1016/j.tranon.2023.101720 Text en © 2023 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Commentary Wang, Wenxiang He, Yue Yang, Fan Chen, Kezhong Current and emerging applications of liquid biopsy in pan-cancer |
title | Current and emerging applications of liquid biopsy in pan-cancer |
title_full | Current and emerging applications of liquid biopsy in pan-cancer |
title_fullStr | Current and emerging applications of liquid biopsy in pan-cancer |
title_full_unstemmed | Current and emerging applications of liquid biopsy in pan-cancer |
title_short | Current and emerging applications of liquid biopsy in pan-cancer |
title_sort | current and emerging applications of liquid biopsy in pan-cancer |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302532/ https://www.ncbi.nlm.nih.gov/pubmed/37315508 http://dx.doi.org/10.1016/j.tranon.2023.101720 |
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