Current and emerging applications of liquid biopsy in pan-cancer

Cancer morbidity and mortality are growing rapidly worldwide and it is urgent to develop a convenient and effective method that can identify cancer patients at an early stage and predict treatment outcomes. As a minimally invasive and reproducible tool, liquid biopsy (LB) offers the opportunity to d...

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Autores principales: Wang, Wenxiang, He, Yue, Yang, Fan, Chen, Kezhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302532/
https://www.ncbi.nlm.nih.gov/pubmed/37315508
http://dx.doi.org/10.1016/j.tranon.2023.101720
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author Wang, Wenxiang
He, Yue
Yang, Fan
Chen, Kezhong
author_facet Wang, Wenxiang
He, Yue
Yang, Fan
Chen, Kezhong
author_sort Wang, Wenxiang
collection PubMed
description Cancer morbidity and mortality are growing rapidly worldwide and it is urgent to develop a convenient and effective method that can identify cancer patients at an early stage and predict treatment outcomes. As a minimally invasive and reproducible tool, liquid biopsy (LB) offers the opportunity to detect, analyze and monitor cancer in any body fluids including blood, complementing the limitations of tissue biopsy. In liquid biopsy, circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are the two most common biomarkers, displaying great potential in the clinical application of pan-cancer. In this review, we expound the samples, targets, and newest techniques in liquid biopsy and summarize current clinical applications in several specific cancers. Besides, we put forward a bright prospect for further exploring the emerging application of liquid biopsy in the field of pan-cancer precision medicine.
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spelling pubmed-103025322023-06-29 Current and emerging applications of liquid biopsy in pan-cancer Wang, Wenxiang He, Yue Yang, Fan Chen, Kezhong Transl Oncol Commentary Cancer morbidity and mortality are growing rapidly worldwide and it is urgent to develop a convenient and effective method that can identify cancer patients at an early stage and predict treatment outcomes. As a minimally invasive and reproducible tool, liquid biopsy (LB) offers the opportunity to detect, analyze and monitor cancer in any body fluids including blood, complementing the limitations of tissue biopsy. In liquid biopsy, circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are the two most common biomarkers, displaying great potential in the clinical application of pan-cancer. In this review, we expound the samples, targets, and newest techniques in liquid biopsy and summarize current clinical applications in several specific cancers. Besides, we put forward a bright prospect for further exploring the emerging application of liquid biopsy in the field of pan-cancer precision medicine. Neoplasia Press 2023-06-12 /pmc/articles/PMC10302532/ /pubmed/37315508 http://dx.doi.org/10.1016/j.tranon.2023.101720 Text en © 2023 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Commentary
Wang, Wenxiang
He, Yue
Yang, Fan
Chen, Kezhong
Current and emerging applications of liquid biopsy in pan-cancer
title Current and emerging applications of liquid biopsy in pan-cancer
title_full Current and emerging applications of liquid biopsy in pan-cancer
title_fullStr Current and emerging applications of liquid biopsy in pan-cancer
title_full_unstemmed Current and emerging applications of liquid biopsy in pan-cancer
title_short Current and emerging applications of liquid biopsy in pan-cancer
title_sort current and emerging applications of liquid biopsy in pan-cancer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302532/
https://www.ncbi.nlm.nih.gov/pubmed/37315508
http://dx.doi.org/10.1016/j.tranon.2023.101720
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