Cargando…

Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy

This study investigated the microstructures, mechanical performances, corrosion resistances, and in vitro studies of porous Ti-xNb-10Zr (x: 10 and 20; at. %) alloys. The alloys were fabricated by powder metallurgy with two categories of porosities, i.e., 21–25% and 50–56%, respectively. The space ho...

Descripción completa

Detalles Bibliográficos
Autores principales: Karakurt, Eyyup Murat, Cetin, Yuksel, Incesu, Alper, Demirtas, Huseyin, Kaya, Mehmet, Yildizhan, Yasemin, Tosun, Merve, Huang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302561/
https://www.ncbi.nlm.nih.gov/pubmed/37374426
http://dx.doi.org/10.3390/ma16124240
_version_ 1785065073117495296
author Karakurt, Eyyup Murat
Cetin, Yuksel
Incesu, Alper
Demirtas, Huseyin
Kaya, Mehmet
Yildizhan, Yasemin
Tosun, Merve
Huang, Yan
author_facet Karakurt, Eyyup Murat
Cetin, Yuksel
Incesu, Alper
Demirtas, Huseyin
Kaya, Mehmet
Yildizhan, Yasemin
Tosun, Merve
Huang, Yan
author_sort Karakurt, Eyyup Murat
collection PubMed
description This study investigated the microstructures, mechanical performances, corrosion resistances, and in vitro studies of porous Ti-xNb-10Zr (x: 10 and 20; at. %) alloys. The alloys were fabricated by powder metallurgy with two categories of porosities, i.e., 21–25% and 50–56%, respectively. The space holder technique was employed to generate the high porosities. Microstructural analysis was performed by using various methods including scanning electron microscopy, energy dispersive spectroscopy, electron backscatter diffraction, and x-ray diffraction. Corrosion resistance was assessed via electrochemical polarisation tests, while mechanical behavior was determined by uniaxial compressive tests. In vitro studies, such as cell viability and proliferation, adhesion potential, and genotoxicity, were examined by performing an MTT assay, fibronectin adsorption, and plasmid-DNA interaction assay. Experimental results showed that the alloys had a dual-phase microstructure composed of finely dispersed acicular hcp α-Ti needles in the bcc β-Ti matrix. The ultimate compressive strength ranged from 1019 MPa to 767 MPa for alloys with 21–25% porosities and from 173 MPa to 78 MPa for alloys with 50–56% porosities. Noted that adding a space holder agent played a more critical role in the mechanical behaviors of the alloys compared to adding niobium. The pores were largely open and exhibited irregular shapes, with uniform size distribution, allowing for cell ingrowth. Histological analysis showed that the alloys studied met the biocompatibility criteria required for orthopaedic biomaterial use.
format Online
Article
Text
id pubmed-10302561
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103025612023-06-29 Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy Karakurt, Eyyup Murat Cetin, Yuksel Incesu, Alper Demirtas, Huseyin Kaya, Mehmet Yildizhan, Yasemin Tosun, Merve Huang, Yan Materials (Basel) Article This study investigated the microstructures, mechanical performances, corrosion resistances, and in vitro studies of porous Ti-xNb-10Zr (x: 10 and 20; at. %) alloys. The alloys were fabricated by powder metallurgy with two categories of porosities, i.e., 21–25% and 50–56%, respectively. The space holder technique was employed to generate the high porosities. Microstructural analysis was performed by using various methods including scanning electron microscopy, energy dispersive spectroscopy, electron backscatter diffraction, and x-ray diffraction. Corrosion resistance was assessed via electrochemical polarisation tests, while mechanical behavior was determined by uniaxial compressive tests. In vitro studies, such as cell viability and proliferation, adhesion potential, and genotoxicity, were examined by performing an MTT assay, fibronectin adsorption, and plasmid-DNA interaction assay. Experimental results showed that the alloys had a dual-phase microstructure composed of finely dispersed acicular hcp α-Ti needles in the bcc β-Ti matrix. The ultimate compressive strength ranged from 1019 MPa to 767 MPa for alloys with 21–25% porosities and from 173 MPa to 78 MPa for alloys with 50–56% porosities. Noted that adding a space holder agent played a more critical role in the mechanical behaviors of the alloys compared to adding niobium. The pores were largely open and exhibited irregular shapes, with uniform size distribution, allowing for cell ingrowth. Histological analysis showed that the alloys studied met the biocompatibility criteria required for orthopaedic biomaterial use. MDPI 2023-06-08 /pmc/articles/PMC10302561/ /pubmed/37374426 http://dx.doi.org/10.3390/ma16124240 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Karakurt, Eyyup Murat
Cetin, Yuksel
Incesu, Alper
Demirtas, Huseyin
Kaya, Mehmet
Yildizhan, Yasemin
Tosun, Merve
Huang, Yan
Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy
title Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy
title_full Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy
title_fullStr Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy
title_full_unstemmed Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy
title_short Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy
title_sort microstructural, biomechanical, and in vitro studies of ti-nb-zr alloys fabricated by powder metallurgy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302561/
https://www.ncbi.nlm.nih.gov/pubmed/37374426
http://dx.doi.org/10.3390/ma16124240
work_keys_str_mv AT karakurteyyupmurat microstructuralbiomechanicalandinvitrostudiesoftinbzralloysfabricatedbypowdermetallurgy
AT cetinyuksel microstructuralbiomechanicalandinvitrostudiesoftinbzralloysfabricatedbypowdermetallurgy
AT incesualper microstructuralbiomechanicalandinvitrostudiesoftinbzralloysfabricatedbypowdermetallurgy
AT demirtashuseyin microstructuralbiomechanicalandinvitrostudiesoftinbzralloysfabricatedbypowdermetallurgy
AT kayamehmet microstructuralbiomechanicalandinvitrostudiesoftinbzralloysfabricatedbypowdermetallurgy
AT yildizhanyasemin microstructuralbiomechanicalandinvitrostudiesoftinbzralloysfabricatedbypowdermetallurgy
AT tosunmerve microstructuralbiomechanicalandinvitrostudiesoftinbzralloysfabricatedbypowdermetallurgy
AT huangyan microstructuralbiomechanicalandinvitrostudiesoftinbzralloysfabricatedbypowdermetallurgy