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A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging

Bone mechanics is well understood at every length scale except the nano-level. We aimed to investigate the relationship between bone nanoscale and tissue-level mechanics experimentally. We tested two hypotheses: (1) nanoscale strains were lower in hip fracture patients versus controls, and (2) nanos...

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Autores principales: Stavri, Richard, Tay, Tabitha, Wiles, Crispin C., Di Federico, Erica, Boughton, Oliver, Ma, Shaocheng, Karunaratne, Angelo, Churchwell, John H., Bhattacharya, Rajarshi, Terrill, Nicholas J., Cobb, Justin P., Hansen, Ulrich, Abel, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302642/
https://www.ncbi.nlm.nih.gov/pubmed/37374160
http://dx.doi.org/10.3390/life13061378
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author Stavri, Richard
Tay, Tabitha
Wiles, Crispin C.
Di Federico, Erica
Boughton, Oliver
Ma, Shaocheng
Karunaratne, Angelo
Churchwell, John H.
Bhattacharya, Rajarshi
Terrill, Nicholas J.
Cobb, Justin P.
Hansen, Ulrich
Abel, Richard L.
author_facet Stavri, Richard
Tay, Tabitha
Wiles, Crispin C.
Di Federico, Erica
Boughton, Oliver
Ma, Shaocheng
Karunaratne, Angelo
Churchwell, John H.
Bhattacharya, Rajarshi
Terrill, Nicholas J.
Cobb, Justin P.
Hansen, Ulrich
Abel, Richard L.
author_sort Stavri, Richard
collection PubMed
description Bone mechanics is well understood at every length scale except the nano-level. We aimed to investigate the relationship between bone nanoscale and tissue-level mechanics experimentally. We tested two hypotheses: (1) nanoscale strains were lower in hip fracture patients versus controls, and (2) nanoscale mineral and fibril strains were inversely correlated with aging and fracture. A cross-sectional sample of trabecular bone sections was prepared from the proximal femora of two human donor groups (aged 44–94 years): an aging non-fracture control group (n = 17) and a hip-fracture group (n = 20). Tissue, fibril, and mineral strain were measured simultaneously using synchrotron X-ray diffraction during tensile load to failure, then compared between groups using unpaired t-tests and correlated with age using Pearson’s correlation. Controls exhibited significantly greater peak tissue, mineral, and fibril strains than the hip fracture (all p < 0.05). Age was associated with a decrease in peak tissue (p = 0.099) and mineral (p = 0.004) strain, but not fibril strain (p = 0.260). Overall, hip fracture and aging were associated with changes in the nanoscale strain that are reflected at the tissue level. Data must be interpreted within the limitations of the observational cross-sectional study design, so we propose two new hypotheses on the importance of nanomechanics. (1) Hip fracture risk is increased by low tissue strain, which can be caused by low collagen or mineral strain. (2) Age-related loss of tissue strain is dependent on the loss of mineral but not fibril strain. Novel insights into bone nano- and tissue-level mechanics could provide a platform for the development of bone health diagnostics and interventions based on failure mechanisms from the nanoscale up.
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spelling pubmed-103026422023-06-29 A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging Stavri, Richard Tay, Tabitha Wiles, Crispin C. Di Federico, Erica Boughton, Oliver Ma, Shaocheng Karunaratne, Angelo Churchwell, John H. Bhattacharya, Rajarshi Terrill, Nicholas J. Cobb, Justin P. Hansen, Ulrich Abel, Richard L. Life (Basel) Article Bone mechanics is well understood at every length scale except the nano-level. We aimed to investigate the relationship between bone nanoscale and tissue-level mechanics experimentally. We tested two hypotheses: (1) nanoscale strains were lower in hip fracture patients versus controls, and (2) nanoscale mineral and fibril strains were inversely correlated with aging and fracture. A cross-sectional sample of trabecular bone sections was prepared from the proximal femora of two human donor groups (aged 44–94 years): an aging non-fracture control group (n = 17) and a hip-fracture group (n = 20). Tissue, fibril, and mineral strain were measured simultaneously using synchrotron X-ray diffraction during tensile load to failure, then compared between groups using unpaired t-tests and correlated with age using Pearson’s correlation. Controls exhibited significantly greater peak tissue, mineral, and fibril strains than the hip fracture (all p < 0.05). Age was associated with a decrease in peak tissue (p = 0.099) and mineral (p = 0.004) strain, but not fibril strain (p = 0.260). Overall, hip fracture and aging were associated with changes in the nanoscale strain that are reflected at the tissue level. Data must be interpreted within the limitations of the observational cross-sectional study design, so we propose two new hypotheses on the importance of nanomechanics. (1) Hip fracture risk is increased by low tissue strain, which can be caused by low collagen or mineral strain. (2) Age-related loss of tissue strain is dependent on the loss of mineral but not fibril strain. Novel insights into bone nano- and tissue-level mechanics could provide a platform for the development of bone health diagnostics and interventions based on failure mechanisms from the nanoscale up. MDPI 2023-06-13 /pmc/articles/PMC10302642/ /pubmed/37374160 http://dx.doi.org/10.3390/life13061378 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stavri, Richard
Tay, Tabitha
Wiles, Crispin C.
Di Federico, Erica
Boughton, Oliver
Ma, Shaocheng
Karunaratne, Angelo
Churchwell, John H.
Bhattacharya, Rajarshi
Terrill, Nicholas J.
Cobb, Justin P.
Hansen, Ulrich
Abel, Richard L.
A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging
title A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging
title_full A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging
title_fullStr A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging
title_full_unstemmed A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging
title_short A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging
title_sort cross-sectional study of bone nanomechanics in hip fracture and aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302642/
https://www.ncbi.nlm.nih.gov/pubmed/37374160
http://dx.doi.org/10.3390/life13061378
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