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Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease

Background: Sarcopenia is thought to be related to an increased risk of non-alcoholic steatohepatitis and advanced liver fibrosis. Our cross-sectional single-center study was designed to analyze the prevalence of sarcopenia in patients with NAFLD and possible influencing factors. Methods: A survey o...

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Autores principales: Sheptulina, Anna F., Yafarova, Adel A., Golubeva, Julia A., Mamutova, Elvira M., Kiselev, Anton R., Drapkina, Oxana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302668/
https://www.ncbi.nlm.nih.gov/pubmed/37373921
http://dx.doi.org/10.3390/jpm13060932
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author Sheptulina, Anna F.
Yafarova, Adel A.
Golubeva, Julia A.
Mamutova, Elvira M.
Kiselev, Anton R.
Drapkina, Oxana M.
author_facet Sheptulina, Anna F.
Yafarova, Adel A.
Golubeva, Julia A.
Mamutova, Elvira M.
Kiselev, Anton R.
Drapkina, Oxana M.
author_sort Sheptulina, Anna F.
collection PubMed
description Background: Sarcopenia is thought to be related to an increased risk of non-alcoholic steatohepatitis and advanced liver fibrosis. Our cross-sectional single-center study was designed to analyze the prevalence of sarcopenia in patients with NAFLD and possible influencing factors. Methods: A survey on the presence of sarcopenia, fatigue, anxiety, and depression, along with a quality-of-life (QoL) assessment, was forwarded by email to 189 outpatients. Demographics, anthropometric and clinical data (laboratory test results and abdomen complete ultrasound protocol), performed within 2–4 weeks prior to the enrollment, were obtained. Results: Sarcopenia (defined as SARC-F score ≥ 4) was identified in 17 (15.7%) patients, all of them (100%) females, with median age (interquartile range) 56 (51–64) years. These patients had a poorer metabolic state (greater values of waist and hip circumferences, body mass index, and HOMA-IR) and significantly poorer QoL, specifically, regarding the physical component of health, compared with NAFLD patients without sarcopenia. Multivariate analysis showed that depression (OR = 1.25, 95% CI: 1.02–1.53, p = 0.035) and clinically meaningful fatigue (OR = 1.14, 95% CI: 1.04–1.26, p = 0.008) were the factors independently associated with sarcopenia in patients with NAFLD. Conclusion: Sarcopenia is associated with depression and fatigue rather than with the severity of liver disease alone and may negatively affect QoL in patients with NAFLD.
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spelling pubmed-103026682023-06-29 Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease Sheptulina, Anna F. Yafarova, Adel A. Golubeva, Julia A. Mamutova, Elvira M. Kiselev, Anton R. Drapkina, Oxana M. J Pers Med Article Background: Sarcopenia is thought to be related to an increased risk of non-alcoholic steatohepatitis and advanced liver fibrosis. Our cross-sectional single-center study was designed to analyze the prevalence of sarcopenia in patients with NAFLD and possible influencing factors. Methods: A survey on the presence of sarcopenia, fatigue, anxiety, and depression, along with a quality-of-life (QoL) assessment, was forwarded by email to 189 outpatients. Demographics, anthropometric and clinical data (laboratory test results and abdomen complete ultrasound protocol), performed within 2–4 weeks prior to the enrollment, were obtained. Results: Sarcopenia (defined as SARC-F score ≥ 4) was identified in 17 (15.7%) patients, all of them (100%) females, with median age (interquartile range) 56 (51–64) years. These patients had a poorer metabolic state (greater values of waist and hip circumferences, body mass index, and HOMA-IR) and significantly poorer QoL, specifically, regarding the physical component of health, compared with NAFLD patients without sarcopenia. Multivariate analysis showed that depression (OR = 1.25, 95% CI: 1.02–1.53, p = 0.035) and clinically meaningful fatigue (OR = 1.14, 95% CI: 1.04–1.26, p = 0.008) were the factors independently associated with sarcopenia in patients with NAFLD. Conclusion: Sarcopenia is associated with depression and fatigue rather than with the severity of liver disease alone and may negatively affect QoL in patients with NAFLD. MDPI 2023-05-31 /pmc/articles/PMC10302668/ /pubmed/37373921 http://dx.doi.org/10.3390/jpm13060932 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sheptulina, Anna F.
Yafarova, Adel A.
Golubeva, Julia A.
Mamutova, Elvira M.
Kiselev, Anton R.
Drapkina, Oxana M.
Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease
title Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease
title_full Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease
title_fullStr Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease
title_full_unstemmed Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease
title_short Clinically Meaningful Fatigue and Depression Are Associated with Sarcopenia in Patients with Non-Alcoholic Fatty Liver Disease
title_sort clinically meaningful fatigue and depression are associated with sarcopenia in patients with non-alcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302668/
https://www.ncbi.nlm.nih.gov/pubmed/37373921
http://dx.doi.org/10.3390/jpm13060932
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