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Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats
Takotsubo syndrome (TTS) is an acute heart failure syndrome characterised by catecholamine-induced oxidative tissue damage. Punica granatum, a fruit-bearing tree, is known to have high polyphenolic content and has been proven to be a potent antioxidant. This study aimed to investigate the effects of...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302705/ https://www.ncbi.nlm.nih.gov/pubmed/37376144 http://dx.doi.org/10.3390/pharmaceutics15061697 |
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author | Marinković, Sonja T. Đukanović, Đorđe Duran, Mladen Bajic, Zorislava Sobot, Tanja Uletilović, Snežana Mandić-Kovacević, Nebojša Cvjetković, Tanja Maksimović, Žana M. Maličević, Uglješa Vesić, Nikolina Jovičić, Sanja Katana, Maja Šavikin, Katarina Djuric, Dragan M. Stojiljković, Miloš P. Škrbić, Ranko |
author_facet | Marinković, Sonja T. Đukanović, Đorđe Duran, Mladen Bajic, Zorislava Sobot, Tanja Uletilović, Snežana Mandić-Kovacević, Nebojša Cvjetković, Tanja Maksimović, Žana M. Maličević, Uglješa Vesić, Nikolina Jovičić, Sanja Katana, Maja Šavikin, Katarina Djuric, Dragan M. Stojiljković, Miloš P. Škrbić, Ranko |
author_sort | Marinković, Sonja T. |
collection | PubMed |
description | Takotsubo syndrome (TTS) is an acute heart failure syndrome characterised by catecholamine-induced oxidative tissue damage. Punica granatum, a fruit-bearing tree, is known to have high polyphenolic content and has been proven to be a potent antioxidant. This study aimed to investigate the effects of pomegranate peel extract (PoPEx) pre-treatment on isoprenaline-induced takotsubo-like myocardial injury in rats. Male Wistar rats were randomised into four groups. Animals in the PoPEx(P) and PoPEx + isoprenaline group (P + I) were pre-treated for 7 days with 100 mg/kg/day of PoPEx. On the sixth and the seventh day, TTS-like syndrome was induced in rats from the isoprenaline(I) and P + I groups by administering 85 mg/kg/day of isoprenaline. PoPEx pre-treatment led to the elevation of superoxide dismutase and catalase (p < 0.05), reduced glutathione (p < 0.001) levels, decreased the thiobarbituric acid reactive substances (p < 0.001), H(2)O(2), O(2)(−) (p < 0.05), and NO(2)(−) (p < 0.001), in the P + I group, when compared to the I group. In addition, a significant reduction in the levels of cardiac damage markers, as well as a reduction in the extent of cardiac damage, was found. In conclusion, PoPEx pre-treatment significantly attenuated the isoprenaline-induced myocardial damage, primarily via the preservation of endogenous antioxidant capacity in the rat model of takotsubo-like cardiomyopathy. |
format | Online Article Text |
id | pubmed-10302705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103027052023-06-29 Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats Marinković, Sonja T. Đukanović, Đorđe Duran, Mladen Bajic, Zorislava Sobot, Tanja Uletilović, Snežana Mandić-Kovacević, Nebojša Cvjetković, Tanja Maksimović, Žana M. Maličević, Uglješa Vesić, Nikolina Jovičić, Sanja Katana, Maja Šavikin, Katarina Djuric, Dragan M. Stojiljković, Miloš P. Škrbić, Ranko Pharmaceutics Article Takotsubo syndrome (TTS) is an acute heart failure syndrome characterised by catecholamine-induced oxidative tissue damage. Punica granatum, a fruit-bearing tree, is known to have high polyphenolic content and has been proven to be a potent antioxidant. This study aimed to investigate the effects of pomegranate peel extract (PoPEx) pre-treatment on isoprenaline-induced takotsubo-like myocardial injury in rats. Male Wistar rats were randomised into four groups. Animals in the PoPEx(P) and PoPEx + isoprenaline group (P + I) were pre-treated for 7 days with 100 mg/kg/day of PoPEx. On the sixth and the seventh day, TTS-like syndrome was induced in rats from the isoprenaline(I) and P + I groups by administering 85 mg/kg/day of isoprenaline. PoPEx pre-treatment led to the elevation of superoxide dismutase and catalase (p < 0.05), reduced glutathione (p < 0.001) levels, decreased the thiobarbituric acid reactive substances (p < 0.001), H(2)O(2), O(2)(−) (p < 0.05), and NO(2)(−) (p < 0.001), in the P + I group, when compared to the I group. In addition, a significant reduction in the levels of cardiac damage markers, as well as a reduction in the extent of cardiac damage, was found. In conclusion, PoPEx pre-treatment significantly attenuated the isoprenaline-induced myocardial damage, primarily via the preservation of endogenous antioxidant capacity in the rat model of takotsubo-like cardiomyopathy. MDPI 2023-06-09 /pmc/articles/PMC10302705/ /pubmed/37376144 http://dx.doi.org/10.3390/pharmaceutics15061697 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Marinković, Sonja T. Đukanović, Đorđe Duran, Mladen Bajic, Zorislava Sobot, Tanja Uletilović, Snežana Mandić-Kovacević, Nebojša Cvjetković, Tanja Maksimović, Žana M. Maličević, Uglješa Vesić, Nikolina Jovičić, Sanja Katana, Maja Šavikin, Katarina Djuric, Dragan M. Stojiljković, Miloš P. Škrbić, Ranko Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats |
title | Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats |
title_full | Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats |
title_fullStr | Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats |
title_full_unstemmed | Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats |
title_short | Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats |
title_sort | pomegranate peel extract attenuates isoprenaline-induced takotsubo-like myocardial injury in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302705/ https://www.ncbi.nlm.nih.gov/pubmed/37376144 http://dx.doi.org/10.3390/pharmaceutics15061697 |
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