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Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats

Takotsubo syndrome (TTS) is an acute heart failure syndrome characterised by catecholamine-induced oxidative tissue damage. Punica granatum, a fruit-bearing tree, is known to have high polyphenolic content and has been proven to be a potent antioxidant. This study aimed to investigate the effects of...

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Autores principales: Marinković, Sonja T., Đukanović, Đorđe, Duran, Mladen, Bajic, Zorislava, Sobot, Tanja, Uletilović, Snežana, Mandić-Kovacević, Nebojša, Cvjetković, Tanja, Maksimović, Žana M., Maličević, Uglješa, Vesić, Nikolina, Jovičić, Sanja, Katana, Maja, Šavikin, Katarina, Djuric, Dragan M., Stojiljković, Miloš P., Škrbić, Ranko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302705/
https://www.ncbi.nlm.nih.gov/pubmed/37376144
http://dx.doi.org/10.3390/pharmaceutics15061697
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author Marinković, Sonja T.
Đukanović, Đorđe
Duran, Mladen
Bajic, Zorislava
Sobot, Tanja
Uletilović, Snežana
Mandić-Kovacević, Nebojša
Cvjetković, Tanja
Maksimović, Žana M.
Maličević, Uglješa
Vesić, Nikolina
Jovičić, Sanja
Katana, Maja
Šavikin, Katarina
Djuric, Dragan M.
Stojiljković, Miloš P.
Škrbić, Ranko
author_facet Marinković, Sonja T.
Đukanović, Đorđe
Duran, Mladen
Bajic, Zorislava
Sobot, Tanja
Uletilović, Snežana
Mandić-Kovacević, Nebojša
Cvjetković, Tanja
Maksimović, Žana M.
Maličević, Uglješa
Vesić, Nikolina
Jovičić, Sanja
Katana, Maja
Šavikin, Katarina
Djuric, Dragan M.
Stojiljković, Miloš P.
Škrbić, Ranko
author_sort Marinković, Sonja T.
collection PubMed
description Takotsubo syndrome (TTS) is an acute heart failure syndrome characterised by catecholamine-induced oxidative tissue damage. Punica granatum, a fruit-bearing tree, is known to have high polyphenolic content and has been proven to be a potent antioxidant. This study aimed to investigate the effects of pomegranate peel extract (PoPEx) pre-treatment on isoprenaline-induced takotsubo-like myocardial injury in rats. Male Wistar rats were randomised into four groups. Animals in the PoPEx(P) and PoPEx + isoprenaline group (P + I) were pre-treated for 7 days with 100 mg/kg/day of PoPEx. On the sixth and the seventh day, TTS-like syndrome was induced in rats from the isoprenaline(I) and P + I groups by administering 85 mg/kg/day of isoprenaline. PoPEx pre-treatment led to the elevation of superoxide dismutase and catalase (p < 0.05), reduced glutathione (p < 0.001) levels, decreased the thiobarbituric acid reactive substances (p < 0.001), H(2)O(2), O(2)(−) (p < 0.05), and NO(2)(−) (p < 0.001), in the P + I group, when compared to the I group. In addition, a significant reduction in the levels of cardiac damage markers, as well as a reduction in the extent of cardiac damage, was found. In conclusion, PoPEx pre-treatment significantly attenuated the isoprenaline-induced myocardial damage, primarily via the preservation of endogenous antioxidant capacity in the rat model of takotsubo-like cardiomyopathy.
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spelling pubmed-103027052023-06-29 Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats Marinković, Sonja T. Đukanović, Đorđe Duran, Mladen Bajic, Zorislava Sobot, Tanja Uletilović, Snežana Mandić-Kovacević, Nebojša Cvjetković, Tanja Maksimović, Žana M. Maličević, Uglješa Vesić, Nikolina Jovičić, Sanja Katana, Maja Šavikin, Katarina Djuric, Dragan M. Stojiljković, Miloš P. Škrbić, Ranko Pharmaceutics Article Takotsubo syndrome (TTS) is an acute heart failure syndrome characterised by catecholamine-induced oxidative tissue damage. Punica granatum, a fruit-bearing tree, is known to have high polyphenolic content and has been proven to be a potent antioxidant. This study aimed to investigate the effects of pomegranate peel extract (PoPEx) pre-treatment on isoprenaline-induced takotsubo-like myocardial injury in rats. Male Wistar rats were randomised into four groups. Animals in the PoPEx(P) and PoPEx + isoprenaline group (P + I) were pre-treated for 7 days with 100 mg/kg/day of PoPEx. On the sixth and the seventh day, TTS-like syndrome was induced in rats from the isoprenaline(I) and P + I groups by administering 85 mg/kg/day of isoprenaline. PoPEx pre-treatment led to the elevation of superoxide dismutase and catalase (p < 0.05), reduced glutathione (p < 0.001) levels, decreased the thiobarbituric acid reactive substances (p < 0.001), H(2)O(2), O(2)(−) (p < 0.05), and NO(2)(−) (p < 0.001), in the P + I group, when compared to the I group. In addition, a significant reduction in the levels of cardiac damage markers, as well as a reduction in the extent of cardiac damage, was found. In conclusion, PoPEx pre-treatment significantly attenuated the isoprenaline-induced myocardial damage, primarily via the preservation of endogenous antioxidant capacity in the rat model of takotsubo-like cardiomyopathy. MDPI 2023-06-09 /pmc/articles/PMC10302705/ /pubmed/37376144 http://dx.doi.org/10.3390/pharmaceutics15061697 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marinković, Sonja T.
Đukanović, Đorđe
Duran, Mladen
Bajic, Zorislava
Sobot, Tanja
Uletilović, Snežana
Mandić-Kovacević, Nebojša
Cvjetković, Tanja
Maksimović, Žana M.
Maličević, Uglješa
Vesić, Nikolina
Jovičić, Sanja
Katana, Maja
Šavikin, Katarina
Djuric, Dragan M.
Stojiljković, Miloš P.
Škrbić, Ranko
Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats
title Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats
title_full Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats
title_fullStr Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats
title_full_unstemmed Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats
title_short Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats
title_sort pomegranate peel extract attenuates isoprenaline-induced takotsubo-like myocardial injury in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302705/
https://www.ncbi.nlm.nih.gov/pubmed/37376144
http://dx.doi.org/10.3390/pharmaceutics15061697
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