Cargando…

Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish

Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Yeonhwa, Kim, Seong Soon, Park, Byeong Heon, Hwang, Kyu-Seok, Bae, Myung Ae, Cho, Sung-Hee, Kim, Suhyun, Park, Hae-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302713/
https://www.ncbi.nlm.nih.gov/pubmed/37368577
http://dx.doi.org/10.3390/toxics11060477
_version_ 1785065108291977216
author Kim, Yeonhwa
Kim, Seong Soon
Park, Byeong Heon
Hwang, Kyu-Seok
Bae, Myung Ae
Cho, Sung-Hee
Kim, Suhyun
Park, Hae-Chul
author_facet Kim, Yeonhwa
Kim, Seong Soon
Park, Byeong Heon
Hwang, Kyu-Seok
Bae, Myung Ae
Cho, Sung-Hee
Kim, Suhyun
Park, Hae-Chul
author_sort Kim, Yeonhwa
collection PubMed
description Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae.
format Online
Article
Text
id pubmed-10302713
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103027132023-06-29 Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish Kim, Yeonhwa Kim, Seong Soon Park, Byeong Heon Hwang, Kyu-Seok Bae, Myung Ae Cho, Sung-Hee Kim, Suhyun Park, Hae-Chul Toxics Article Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae. MDPI 2023-05-24 /pmc/articles/PMC10302713/ /pubmed/37368577 http://dx.doi.org/10.3390/toxics11060477 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Yeonhwa
Kim, Seong Soon
Park, Byeong Heon
Hwang, Kyu-Seok
Bae, Myung Ae
Cho, Sung-Hee
Kim, Suhyun
Park, Hae-Chul
Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
title Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
title_full Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
title_fullStr Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
title_full_unstemmed Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
title_short Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
title_sort mechanism of bisphenol f affecting motor system and motor activity in zebrafish
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302713/
https://www.ncbi.nlm.nih.gov/pubmed/37368577
http://dx.doi.org/10.3390/toxics11060477
work_keys_str_mv AT kimyeonhwa mechanismofbisphenolfaffectingmotorsystemandmotoractivityinzebrafish
AT kimseongsoon mechanismofbisphenolfaffectingmotorsystemandmotoractivityinzebrafish
AT parkbyeongheon mechanismofbisphenolfaffectingmotorsystemandmotoractivityinzebrafish
AT hwangkyuseok mechanismofbisphenolfaffectingmotorsystemandmotoractivityinzebrafish
AT baemyungae mechanismofbisphenolfaffectingmotorsystemandmotoractivityinzebrafish
AT chosunghee mechanismofbisphenolfaffectingmotorsystemandmotoractivityinzebrafish
AT kimsuhyun mechanismofbisphenolfaffectingmotorsystemandmotoractivityinzebrafish
AT parkhaechul mechanismofbisphenolfaffectingmotorsystemandmotoractivityinzebrafish