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Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish
Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302713/ https://www.ncbi.nlm.nih.gov/pubmed/37368577 http://dx.doi.org/10.3390/toxics11060477 |
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author | Kim, Yeonhwa Kim, Seong Soon Park, Byeong Heon Hwang, Kyu-Seok Bae, Myung Ae Cho, Sung-Hee Kim, Suhyun Park, Hae-Chul |
author_facet | Kim, Yeonhwa Kim, Seong Soon Park, Byeong Heon Hwang, Kyu-Seok Bae, Myung Ae Cho, Sung-Hee Kim, Suhyun Park, Hae-Chul |
author_sort | Kim, Yeonhwa |
collection | PubMed |
description | Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae. |
format | Online Article Text |
id | pubmed-10302713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103027132023-06-29 Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish Kim, Yeonhwa Kim, Seong Soon Park, Byeong Heon Hwang, Kyu-Seok Bae, Myung Ae Cho, Sung-Hee Kim, Suhyun Park, Hae-Chul Toxics Article Bisphenol F (BPF; 4,4′-dihydroxydiphenylmethane) is one of the most frequently used compounds in the manufacture of plastics and epoxy resins. Previous studies have demonstrated that BPF affects locomotor behavior, oxidative stress, and neurodevelopment in zebrafish. However, its neurotoxic effects are controversial, and the underlying mechanisms are unclear. In order to determine whether BPF affects the motor system, we exposed zebrafish embryos to BPF and assessed behavioral, histological, and neurochemical changes. Spontaneous locomotor behavior and startle response were significantly decreased in BPF-treated zebrafish larvae compared with control larvae. BPF induced motor degeneration and myelination defects in zebrafish larvae. In addition, embryonic exposure to BPF resulted in altered metabolic profiles of neurochemicals, including neurotransmitters and neurosteroids, which may impact locomotion and motor function. In conclusion, exposure to BPF has the potential to affect survival, motor axon length, locomotor activity, myelination, and neurochemical levels of zebrafish larvae. MDPI 2023-05-24 /pmc/articles/PMC10302713/ /pubmed/37368577 http://dx.doi.org/10.3390/toxics11060477 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Yeonhwa Kim, Seong Soon Park, Byeong Heon Hwang, Kyu-Seok Bae, Myung Ae Cho, Sung-Hee Kim, Suhyun Park, Hae-Chul Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish |
title | Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish |
title_full | Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish |
title_fullStr | Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish |
title_full_unstemmed | Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish |
title_short | Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish |
title_sort | mechanism of bisphenol f affecting motor system and motor activity in zebrafish |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302713/ https://www.ncbi.nlm.nih.gov/pubmed/37368577 http://dx.doi.org/10.3390/toxics11060477 |
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