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Markov State Models Reconcile Conformational Plasticity of GTPase with Its Substrate Binding Event
[Image: see text] Ras GTPase is an enzyme that catalyzes the hydrolysis of guanosine triphosphate (GTP) and plays an important role in controlling crucial cellular signaling pathways. However, this enzyme has always been believed to be undruggable due to its strong binding affinity with its native s...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302740/ https://www.ncbi.nlm.nih.gov/pubmed/37388689 http://dx.doi.org/10.1021/jacsau.3c00151 |