Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3

Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (...

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Detalles Bibliográficos
Autores principales: Chen, Ying, Li, Hongyan, Wang, Ke, Wang, Yousheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302796/
https://www.ncbi.nlm.nih.gov/pubmed/37375294
http://dx.doi.org/10.3390/molecules28124740
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author Chen, Ying
Li, Hongyan
Wang, Ke
Wang, Yousheng
author_facet Chen, Ying
Li, Hongyan
Wang, Ke
Wang, Yousheng
author_sort Chen, Ying
collection PubMed
description Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (HDIs) mediated by OAT3, and inhibitors of OAT3 in natural active compounds in the past decade. This provides a valuable reference for the combined use of substrate drugs/herbs for OAT3 in clinical practice in the future and for the screening of OAT3 inhibitors to avoid harmful interactions.
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spelling pubmed-103027962023-06-29 Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3 Chen, Ying Li, Hongyan Wang, Ke Wang, Yousheng Molecules Review Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (HDIs) mediated by OAT3, and inhibitors of OAT3 in natural active compounds in the past decade. This provides a valuable reference for the combined use of substrate drugs/herbs for OAT3 in clinical practice in the future and for the screening of OAT3 inhibitors to avoid harmful interactions. MDPI 2023-06-13 /pmc/articles/PMC10302796/ /pubmed/37375294 http://dx.doi.org/10.3390/molecules28124740 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Ying
Li, Hongyan
Wang, Ke
Wang, Yousheng
Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
title Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
title_full Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
title_fullStr Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
title_full_unstemmed Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
title_short Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
title_sort recent advances in synthetic drugs and natural actives interacting with oat3
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302796/
https://www.ncbi.nlm.nih.gov/pubmed/37375294
http://dx.doi.org/10.3390/molecules28124740
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