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Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden

There is a lack of research on women with infertility in the northern latitudes, where vitamin D insufficiency is high. Therefore, this study aimed to assess the prevalence and determinants of vitamin D insufficiency (serum 25(OH)D concentration < 50 nmol/L) among women undergoing in vitro fertil...

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Autores principales: Maaherra Armstrong, Paulina, Augustin, Hanna, Bärebring, Linnea, Osmancevic, Amra, Bullarbo, Maria, Thurin-Kjellberg, Ann, Tsiartas, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302815/
https://www.ncbi.nlm.nih.gov/pubmed/37375724
http://dx.doi.org/10.3390/nu15122820
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author Maaherra Armstrong, Paulina
Augustin, Hanna
Bärebring, Linnea
Osmancevic, Amra
Bullarbo, Maria
Thurin-Kjellberg, Ann
Tsiartas, Panagiotis
author_facet Maaherra Armstrong, Paulina
Augustin, Hanna
Bärebring, Linnea
Osmancevic, Amra
Bullarbo, Maria
Thurin-Kjellberg, Ann
Tsiartas, Panagiotis
author_sort Maaherra Armstrong, Paulina
collection PubMed
description There is a lack of research on women with infertility in the northern latitudes, where vitamin D insufficiency is high. Therefore, this study aimed to assess the prevalence and determinants of vitamin D insufficiency (serum 25(OH)D concentration < 50 nmol/L) among women undergoing in vitro fertilization (IVF) treatment. Thus, 265 women scheduled for IVF/intracytoplasmic sperm injection (ICSI) between September 2020 and August 2021 at Sahlgrenska University Hospital in Gothenburg, Sweden, were included. Data on serum 25(OH)D concentration, vitamin D intake, and sun exposure were collected via questionnaires and blood samples. Approximately 27% of the women had 25(OH)D insufficiency, which was associated with longer infertility duration. The likelihood of insufficiency was higher among women from non-Nordic European countries (OR 2.92, 95% CI 1.03–8.26, adjusted p = 0.043), the Middle East (OR 9.90, 95% CI 3.32–29.41, adjusted p < 0.001), and Asia (OR 5.49, 95% CI 1.30–23.25, adjusted p = 0.020) than among women from Nordic countries. Women who did not use vitamin D supplements were more likely to have insufficiency compared with supplement users (OR 3.32, 95% CI 1.55–7.10, adjusted p = 0.002), and those who avoided sun exposure had higher odds of insufficiency compared to those who stayed “in the sun all the time” (OR 3.24, 95% CI 1.22–8.62, adjusted p = 0.018). Women with infertility in northern latitudes and those from non-Nordic countries who avoid sun exposure and do not take vitamin supplements have a higher prevalence of 25(OH)D insufficiency and longer infertility duration.
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spelling pubmed-103028152023-06-29 Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden Maaherra Armstrong, Paulina Augustin, Hanna Bärebring, Linnea Osmancevic, Amra Bullarbo, Maria Thurin-Kjellberg, Ann Tsiartas, Panagiotis Nutrients Article There is a lack of research on women with infertility in the northern latitudes, where vitamin D insufficiency is high. Therefore, this study aimed to assess the prevalence and determinants of vitamin D insufficiency (serum 25(OH)D concentration < 50 nmol/L) among women undergoing in vitro fertilization (IVF) treatment. Thus, 265 women scheduled for IVF/intracytoplasmic sperm injection (ICSI) between September 2020 and August 2021 at Sahlgrenska University Hospital in Gothenburg, Sweden, were included. Data on serum 25(OH)D concentration, vitamin D intake, and sun exposure were collected via questionnaires and blood samples. Approximately 27% of the women had 25(OH)D insufficiency, which was associated with longer infertility duration. The likelihood of insufficiency was higher among women from non-Nordic European countries (OR 2.92, 95% CI 1.03–8.26, adjusted p = 0.043), the Middle East (OR 9.90, 95% CI 3.32–29.41, adjusted p < 0.001), and Asia (OR 5.49, 95% CI 1.30–23.25, adjusted p = 0.020) than among women from Nordic countries. Women who did not use vitamin D supplements were more likely to have insufficiency compared with supplement users (OR 3.32, 95% CI 1.55–7.10, adjusted p = 0.002), and those who avoided sun exposure had higher odds of insufficiency compared to those who stayed “in the sun all the time” (OR 3.24, 95% CI 1.22–8.62, adjusted p = 0.018). Women with infertility in northern latitudes and those from non-Nordic countries who avoid sun exposure and do not take vitamin supplements have a higher prevalence of 25(OH)D insufficiency and longer infertility duration. MDPI 2023-06-20 /pmc/articles/PMC10302815/ /pubmed/37375724 http://dx.doi.org/10.3390/nu15122820 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maaherra Armstrong, Paulina
Augustin, Hanna
Bärebring, Linnea
Osmancevic, Amra
Bullarbo, Maria
Thurin-Kjellberg, Ann
Tsiartas, Panagiotis
Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden
title Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden
title_full Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden
title_fullStr Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden
title_full_unstemmed Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden
title_short Prevalence of Vitamin D Insufficiency and Its Determinants among Women Undergoing In Vitro Fertilization Treatment for Infertility in Sweden
title_sort prevalence of vitamin d insufficiency and its determinants among women undergoing in vitro fertilization treatment for infertility in sweden
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302815/
https://www.ncbi.nlm.nih.gov/pubmed/37375724
http://dx.doi.org/10.3390/nu15122820
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