Cargando…

Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention

Autophagy is a physiological mechanism in which cells degrade themselves and quickly recover the degraded cell components. Recent studies have shown that autophagy plays an important role in the occurrence, development, treatment, and prognosis of colorectal cancer. In the early stages of colorectal...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Tian-Fei, Fan, Yue-Ren, Zhao, Yi-Hang, Liu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302997/
https://www.ncbi.nlm.nih.gov/pubmed/37389106
http://dx.doi.org/10.4251/wjgo.v15.i6.979
_version_ 1785065174801055744
author Ma, Tian-Fei
Fan, Yue-Ren
Zhao, Yi-Hang
Liu, Bin
author_facet Ma, Tian-Fei
Fan, Yue-Ren
Zhao, Yi-Hang
Liu, Bin
author_sort Ma, Tian-Fei
collection PubMed
description Autophagy is a physiological mechanism in which cells degrade themselves and quickly recover the degraded cell components. Recent studies have shown that autophagy plays an important role in the occurrence, development, treatment, and prognosis of colorectal cancer. In the early stages of colorectal cancer, autophagy can inhibit the production and development of tumors through multiple mechanisms such as maintaining DNA stability, inducing tumor death, and enhancing immune surveillance. However, as colorectal cancer progresses, autophagy may mediate tumor resistance, enhance tumor metabolism, and other pathways to promote tumor development. Therefore, intervening in autophagy at the appropriate time has broad clinical application prospects. This article summarizes the recent research progress of autophagy and colorectal cancer and is expected to provide new theoretical basis and reference for clinical treatment of colorectal cancer.
format Online
Article
Text
id pubmed-10302997
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-103029972023-06-29 Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention Ma, Tian-Fei Fan, Yue-Ren Zhao, Yi-Hang Liu, Bin World J Gastrointest Oncol Minireviews Autophagy is a physiological mechanism in which cells degrade themselves and quickly recover the degraded cell components. Recent studies have shown that autophagy plays an important role in the occurrence, development, treatment, and prognosis of colorectal cancer. In the early stages of colorectal cancer, autophagy can inhibit the production and development of tumors through multiple mechanisms such as maintaining DNA stability, inducing tumor death, and enhancing immune surveillance. However, as colorectal cancer progresses, autophagy may mediate tumor resistance, enhance tumor metabolism, and other pathways to promote tumor development. Therefore, intervening in autophagy at the appropriate time has broad clinical application prospects. This article summarizes the recent research progress of autophagy and colorectal cancer and is expected to provide new theoretical basis and reference for clinical treatment of colorectal cancer. Baishideng Publishing Group Inc 2023-06-15 2023-06-15 /pmc/articles/PMC10302997/ /pubmed/37389106 http://dx.doi.org/10.4251/wjgo.v15.i6.979 Text en ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Ma, Tian-Fei
Fan, Yue-Ren
Zhao, Yi-Hang
Liu, Bin
Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention
title Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention
title_full Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention
title_fullStr Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention
title_full_unstemmed Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention
title_short Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention
title_sort emerging role of autophagy in colorectal cancer: progress and prospects for clinical intervention
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302997/
https://www.ncbi.nlm.nih.gov/pubmed/37389106
http://dx.doi.org/10.4251/wjgo.v15.i6.979
work_keys_str_mv AT matianfei emergingroleofautophagyincolorectalcancerprogressandprospectsforclinicalintervention
AT fanyueren emergingroleofautophagyincolorectalcancerprogressandprospectsforclinicalintervention
AT zhaoyihang emergingroleofautophagyincolorectalcancerprogressandprospectsforclinicalintervention
AT liubin emergingroleofautophagyincolorectalcancerprogressandprospectsforclinicalintervention