Cargando…

The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis

Introduction. The pathogenesis of aortic stenosis includes the processes of chronic inflammation, calcification, lipid metabolism disorders, and congenital structural changes. The goal of our study was to determine the predictive value of novel biomarkers of systemic inflammation and some hematologi...

Descripción completa

Detalles Bibliográficos
Autores principales: Shvartz, Vladimir, Sokolskaya, Maria, Ispiryan, Artak, Basieva, Madina, Kazanova, Polina, Shvartz, Elena, Talibova, Sayali, Petrosyan, Andrey, Kanametov, Teymuraz, Donakanyan, Sergey, Bockeria, Leo, Golukhova, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303001/
https://www.ncbi.nlm.nih.gov/pubmed/37374176
http://dx.doi.org/10.3390/life13061395
_version_ 1785065175870603264
author Shvartz, Vladimir
Sokolskaya, Maria
Ispiryan, Artak
Basieva, Madina
Kazanova, Polina
Shvartz, Elena
Talibova, Sayali
Petrosyan, Andrey
Kanametov, Teymuraz
Donakanyan, Sergey
Bockeria, Leo
Golukhova, Elena
author_facet Shvartz, Vladimir
Sokolskaya, Maria
Ispiryan, Artak
Basieva, Madina
Kazanova, Polina
Shvartz, Elena
Talibova, Sayali
Petrosyan, Andrey
Kanametov, Teymuraz
Donakanyan, Sergey
Bockeria, Leo
Golukhova, Elena
author_sort Shvartz, Vladimir
collection PubMed
description Introduction. The pathogenesis of aortic stenosis includes the processes of chronic inflammation, calcification, lipid metabolism disorders, and congenital structural changes. The goal of our study was to determine the predictive value of novel biomarkers of systemic inflammation and some hematological indices based on the numbers of leukocytes and their subtypes in the development of early hospital medical conditions after mechanical aortic valve replacement in patients with aortic stenosis. Materials and methods. This was a cohort study involving 363 patients who underwent surgical intervention for aortic valve pathology between 2014 and 2020. The following markers of systemic inflammation and hematological indices were studied: SIRI (Systemic Inflammation Response Index), SII (Systemic Inflammation Index), AISI (Aggregate Index of Systemic Inflammation), NLR (Neutrophil/Lymphocyte Ratio), PLR (Platelet/Lymphocyte Ratio), and MLR (Monocyte/Lymphocyte Ratio). Associations of the levels of these biomarkers and indices with the development of in-hospital death, acute kidney injury, postoperative atrial fibrillation, stroke/acute cerebrovascular accident, and bleeding were calculated. Results. According to an ROC analysis, an SIRI > 1.5 (p < 0.001), an SII > 718 (p = 0.002), an AISI > 593 (p < 0.001), an NLR > 2.48 (p < 0.001), a PLR > 132 (p = 0.004), and an MLR > 0.332 (p < 0.001) were statistically significantly associated with in-hospital death. Additionally, an SIRI > 1.5 (p < 0.001), an NLR > 2.8 (p < 0.001), and an MLR > 0.392 (p < 0.001) were associated with bleeding in the postoperative period. In a univariate logistic regression, SIRI, SII, AISI, and NLR were statistically significant independent factors associated with in-hospital death. In a multivariate logistic regression model, SIRI was the most powerful marker of systemic inflammation. Conclusion. SIRI, SII, AISI, and NLR as novel biomarkers of systemic inflammation were associated with in-hospital mortality. Of all markers and indices of systemic inflammation in our study, SIRI was the strongest predictor of a poor outcome in the multivariate regression model.
format Online
Article
Text
id pubmed-10303001
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103030012023-06-29 The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis Shvartz, Vladimir Sokolskaya, Maria Ispiryan, Artak Basieva, Madina Kazanova, Polina Shvartz, Elena Talibova, Sayali Petrosyan, Andrey Kanametov, Teymuraz Donakanyan, Sergey Bockeria, Leo Golukhova, Elena Life (Basel) Article Introduction. The pathogenesis of aortic stenosis includes the processes of chronic inflammation, calcification, lipid metabolism disorders, and congenital structural changes. The goal of our study was to determine the predictive value of novel biomarkers of systemic inflammation and some hematological indices based on the numbers of leukocytes and their subtypes in the development of early hospital medical conditions after mechanical aortic valve replacement in patients with aortic stenosis. Materials and methods. This was a cohort study involving 363 patients who underwent surgical intervention for aortic valve pathology between 2014 and 2020. The following markers of systemic inflammation and hematological indices were studied: SIRI (Systemic Inflammation Response Index), SII (Systemic Inflammation Index), AISI (Aggregate Index of Systemic Inflammation), NLR (Neutrophil/Lymphocyte Ratio), PLR (Platelet/Lymphocyte Ratio), and MLR (Monocyte/Lymphocyte Ratio). Associations of the levels of these biomarkers and indices with the development of in-hospital death, acute kidney injury, postoperative atrial fibrillation, stroke/acute cerebrovascular accident, and bleeding were calculated. Results. According to an ROC analysis, an SIRI > 1.5 (p < 0.001), an SII > 718 (p = 0.002), an AISI > 593 (p < 0.001), an NLR > 2.48 (p < 0.001), a PLR > 132 (p = 0.004), and an MLR > 0.332 (p < 0.001) were statistically significantly associated with in-hospital death. Additionally, an SIRI > 1.5 (p < 0.001), an NLR > 2.8 (p < 0.001), and an MLR > 0.392 (p < 0.001) were associated with bleeding in the postoperative period. In a univariate logistic regression, SIRI, SII, AISI, and NLR were statistically significant independent factors associated with in-hospital death. In a multivariate logistic regression model, SIRI was the most powerful marker of systemic inflammation. Conclusion. SIRI, SII, AISI, and NLR as novel biomarkers of systemic inflammation were associated with in-hospital mortality. Of all markers and indices of systemic inflammation in our study, SIRI was the strongest predictor of a poor outcome in the multivariate regression model. MDPI 2023-06-14 /pmc/articles/PMC10303001/ /pubmed/37374176 http://dx.doi.org/10.3390/life13061395 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shvartz, Vladimir
Sokolskaya, Maria
Ispiryan, Artak
Basieva, Madina
Kazanova, Polina
Shvartz, Elena
Talibova, Sayali
Petrosyan, Andrey
Kanametov, Teymuraz
Donakanyan, Sergey
Bockeria, Leo
Golukhova, Elena
The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis
title The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis
title_full The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis
title_fullStr The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis
title_full_unstemmed The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis
title_short The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis
title_sort role of «novel» biomarkers of systemic inflammation in the development of early hospital events after aortic valve replacement in patients with aortic stenosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303001/
https://www.ncbi.nlm.nih.gov/pubmed/37374176
http://dx.doi.org/10.3390/life13061395
work_keys_str_mv AT shvartzvladimir theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT sokolskayamaria theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT ispiryanartak theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT basievamadina theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT kazanovapolina theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT shvartzelena theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT talibovasayali theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT petrosyanandrey theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT kanametovteymuraz theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT donakanyansergey theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT bockerialeo theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT golukhovaelena theroleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT shvartzvladimir roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT sokolskayamaria roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT ispiryanartak roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT basievamadina roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT kazanovapolina roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT shvartzelena roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT talibovasayali roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT petrosyanandrey roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT kanametovteymuraz roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT donakanyansergey roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT bockerialeo roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis
AT golukhovaelena roleofnovelbiomarkersofsystemicinflammationinthedevelopmentofearlyhospitaleventsafteraorticvalvereplacementinpatientswithaorticstenosis