Chloroquine and Hydroxychloroquine, as Proteasome Inhibitors, Upregulate the Expression and Activity of Organic Anion Transporter 3

Organic anion transporter 3 (OAT3), at the basolateral membrane of kidney proximal tubule cells, facilitates the elimination of numerous widely used drugs. Earlier investigation from our laboratory revealed that ubiquitin conjugation to OAT3 leads to OAT3 internalization from the cell surface, follo...

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Detalles Bibliográficos
Autores principales: Liang, Zhengxuan, You, Guofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303059/
https://www.ncbi.nlm.nih.gov/pubmed/37376173
http://dx.doi.org/10.3390/pharmaceutics15061725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303059/
https://www.ncbi.nlm.nih.gov/pubmed/37376173
http://dx.doi.org/10.3390/pharmaceutics15061725

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