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The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients

Objective: The impact of severe infection from COVID-19 and the resulting need for life support in an ICU environment is a fact that caused immense pressure in healthcare systems around the globe. Accordingly, elderly people faced multiple challenges, especially after admission to the ICU. On this b...

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Autores principales: Bakakos, Agamemnon, Koukaki, Evangelia, Ampelioti, Sevasti, Ioannidou, Iliana, Papaioannou, Andriana I., Loverdos, Konstantinos, Koutsoukou, Antonia, Rovina, Nikoleta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303099/
https://www.ncbi.nlm.nih.gov/pubmed/37373897
http://dx.doi.org/10.3390/jpm13060908
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author Bakakos, Agamemnon
Koukaki, Evangelia
Ampelioti, Sevasti
Ioannidou, Iliana
Papaioannou, Andriana I.
Loverdos, Konstantinos
Koutsoukou, Antonia
Rovina, Nikoleta
author_facet Bakakos, Agamemnon
Koukaki, Evangelia
Ampelioti, Sevasti
Ioannidou, Iliana
Papaioannou, Andriana I.
Loverdos, Konstantinos
Koutsoukou, Antonia
Rovina, Nikoleta
author_sort Bakakos, Agamemnon
collection PubMed
description Objective: The impact of severe infection from COVID-19 and the resulting need for life support in an ICU environment is a fact that caused immense pressure in healthcare systems around the globe. Accordingly, elderly people faced multiple challenges, especially after admission to the ICU. On this basis, we performed this study to assess the impact of age on COVID-19 mortality in critically ill patients. Materials and Methods: In this retrospective study, we collected data from 300 patients who were hospitalized in the ICU of a Greek respiratory hospital. We split patients into two age groups using a threshold of 65 years old. The primary objective of the study was the survival of patients in a follow up period of 60 days after their admission to the ICU. Secondary objectives were to determine whether mortality is affected by other factors, including sepsis and clinical and laboratory factors, Charlson Comorbidity Index (CCI), APACHE II and d-dimers, CRP, etc. Results: The survival of all patients in the ICU was 75.7%. Those in the <65 years old age group expressed a survival rate of 89.3%, whereas those in the ≥65 years old age group had a survival rate of 58% (p-value < 0.001). In the multivariate Cox regression, the presence of sepsis and an increased CCI were independent predictors of mortality in 60 days (p-value < 0.001), while the age group did not maintain its statistical significance (p-value = 0.320). Conclusions: Age alone as a simple number is not capable of predicting mortality in patients with severe COVID-19 in the ICU. We must use more composite clinical markers that may better reflect the biological age of patients, such as CCI. Moreover, the effective control of infections in the ICU is of utmost importance for the survival of patients, since avoiding septic complications can drastically improve the prognosis of all patients, regardless of age.
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spelling pubmed-103030992023-06-29 The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients Bakakos, Agamemnon Koukaki, Evangelia Ampelioti, Sevasti Ioannidou, Iliana Papaioannou, Andriana I. Loverdos, Konstantinos Koutsoukou, Antonia Rovina, Nikoleta J Pers Med Article Objective: The impact of severe infection from COVID-19 and the resulting need for life support in an ICU environment is a fact that caused immense pressure in healthcare systems around the globe. Accordingly, elderly people faced multiple challenges, especially after admission to the ICU. On this basis, we performed this study to assess the impact of age on COVID-19 mortality in critically ill patients. Materials and Methods: In this retrospective study, we collected data from 300 patients who were hospitalized in the ICU of a Greek respiratory hospital. We split patients into two age groups using a threshold of 65 years old. The primary objective of the study was the survival of patients in a follow up period of 60 days after their admission to the ICU. Secondary objectives were to determine whether mortality is affected by other factors, including sepsis and clinical and laboratory factors, Charlson Comorbidity Index (CCI), APACHE II and d-dimers, CRP, etc. Results: The survival of all patients in the ICU was 75.7%. Those in the <65 years old age group expressed a survival rate of 89.3%, whereas those in the ≥65 years old age group had a survival rate of 58% (p-value < 0.001). In the multivariate Cox regression, the presence of sepsis and an increased CCI were independent predictors of mortality in 60 days (p-value < 0.001), while the age group did not maintain its statistical significance (p-value = 0.320). Conclusions: Age alone as a simple number is not capable of predicting mortality in patients with severe COVID-19 in the ICU. We must use more composite clinical markers that may better reflect the biological age of patients, such as CCI. Moreover, the effective control of infections in the ICU is of utmost importance for the survival of patients, since avoiding septic complications can drastically improve the prognosis of all patients, regardless of age. MDPI 2023-05-29 /pmc/articles/PMC10303099/ /pubmed/37373897 http://dx.doi.org/10.3390/jpm13060908 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bakakos, Agamemnon
Koukaki, Evangelia
Ampelioti, Sevasti
Ioannidou, Iliana
Papaioannou, Andriana I.
Loverdos, Konstantinos
Koutsoukou, Antonia
Rovina, Nikoleta
The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients
title The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients
title_full The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients
title_fullStr The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients
title_full_unstemmed The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients
title_short The Real Impact of Age on Mortality in Critically Ill COVID-19 Patients
title_sort real impact of age on mortality in critically ill covid-19 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303099/
https://www.ncbi.nlm.nih.gov/pubmed/37373897
http://dx.doi.org/10.3390/jpm13060908
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