Absolute Affinities from Quantitative Shotgun Glycomics Using Concentration-Independent (COIN) Native Mass Spectrometry

[Image: see text] Native mass spectrometry (nMS) screening of natural glycan libraries against glycan-binding proteins (GBPs) is a powerful tool for ligand discovery. However, as the glycan concentrations are unknown, affinities cannot be measured directly from natural libraries. Here, we introduce...

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Detalles Bibliográficos
Autores principales: Bui, Duong T., Favell, James, Kitova, Elena N., Li, Zhixiong, McCord, Kelli A., Schmidt, Edward N., Mozaneh, Fahima, Elaish, Mohamed, El-Hawiet, Amr, St-Pierre, Yves, Hobman, Tom C., Macauley, Matthew S., Mahal, Lara K., Flynn, Morris R., Klassen, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303200/
https://www.ncbi.nlm.nih.gov/pubmed/37521792
http://dx.doi.org/10.1021/acscentsci.3c00294

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