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The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

Introduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of hyponatremia in cancer patients, occurring most frequently in patients with small cell lung cancer. However, this syndrome occurs extremely rarely in patients with non-small cell lung cance...

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Autores principales: Rahnea-Nita, Roxana-Andreea, Stoian, Alexandru-Rares, Anghel, Rodica-Maricela, Rebegea, Laura-Florentina, Ciuhu, Anda-Natalia, Bacinschi, Xenia-Elena, Zgura, Anca-Florina, Trifanescu, Oana-Gabriela, Toma, Radu-Valeriu, Constantin, Georgiana Bianca, Rahnea-Nita, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303290/
https://www.ncbi.nlm.nih.gov/pubmed/37374062
http://dx.doi.org/10.3390/life13061279
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author Rahnea-Nita, Roxana-Andreea
Stoian, Alexandru-Rares
Anghel, Rodica-Maricela
Rebegea, Laura-Florentina
Ciuhu, Anda-Natalia
Bacinschi, Xenia-Elena
Zgura, Anca-Florina
Trifanescu, Oana-Gabriela
Toma, Radu-Valeriu
Constantin, Georgiana Bianca
Rahnea-Nita, Gabriela
author_facet Rahnea-Nita, Roxana-Andreea
Stoian, Alexandru-Rares
Anghel, Rodica-Maricela
Rebegea, Laura-Florentina
Ciuhu, Anda-Natalia
Bacinschi, Xenia-Elena
Zgura, Anca-Florina
Trifanescu, Oana-Gabriela
Toma, Radu-Valeriu
Constantin, Georgiana Bianca
Rahnea-Nita, Gabriela
author_sort Rahnea-Nita, Roxana-Andreea
collection PubMed
description Introduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of hyponatremia in cancer patients, occurring most frequently in patients with small cell lung cancer. However, this syndrome occurs extremely rarely in patients with non-small cell lung cancer. The results of the clinical trials have revealed that immuno-oncological therapies are effective for long periods of time, providing hope for long survival and with a good quality of life. Case Presentation: We present the case of a female patient who was 62 years old at the time of diagnosis in 2016 who underwent surgery for a right pulmonary tumor (pulmonary adenocarcinoma) and subsequently underwent adjuvant chemotherapy. The patient had a left inoperable mediastinohilar relapse in 2018, which was treated using polychemotherapy The patient also had an occurrence of progressive metastasis and a syndrome of inappropriate antidiuretic hormone secretion (SIADH) in 2019 for which immunotherapy was initiated. The patient has continued with immunotherapy until the time this study began to be written (April 2023), the results being the remission of hyponatremia, the clinical benefits and long-term survival. Discussion: The main therapeutic option for SIADH in cancer patients is the treatment of the underlying disease, and its correction depends almost exclusively on a good response to oncological therapy. The initiation of immunotherapy at the time of severe hyponatremia occurrence led to its remission as well as the remission of the other two episodes of hyponatremia, which the patient presented throughout the evolution of the disease, demonstrating an obvious causal relationship between SIADH and the favorable response to immunotherapy. Conclusions: Each patient must be approached individually, taking into account the various particular aspects. Immunotherapy proves to be the innovative treatment that contributes to increasing the survival of patients with metastatic non-small cell lung cancer and to increasing their quality of life.
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spelling pubmed-103032902023-06-29 The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Rahnea-Nita, Roxana-Andreea Stoian, Alexandru-Rares Anghel, Rodica-Maricela Rebegea, Laura-Florentina Ciuhu, Anda-Natalia Bacinschi, Xenia-Elena Zgura, Anca-Florina Trifanescu, Oana-Gabriela Toma, Radu-Valeriu Constantin, Georgiana Bianca Rahnea-Nita, Gabriela Life (Basel) Case Report Introduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of hyponatremia in cancer patients, occurring most frequently in patients with small cell lung cancer. However, this syndrome occurs extremely rarely in patients with non-small cell lung cancer. The results of the clinical trials have revealed that immuno-oncological therapies are effective for long periods of time, providing hope for long survival and with a good quality of life. Case Presentation: We present the case of a female patient who was 62 years old at the time of diagnosis in 2016 who underwent surgery for a right pulmonary tumor (pulmonary adenocarcinoma) and subsequently underwent adjuvant chemotherapy. The patient had a left inoperable mediastinohilar relapse in 2018, which was treated using polychemotherapy The patient also had an occurrence of progressive metastasis and a syndrome of inappropriate antidiuretic hormone secretion (SIADH) in 2019 for which immunotherapy was initiated. The patient has continued with immunotherapy until the time this study began to be written (April 2023), the results being the remission of hyponatremia, the clinical benefits and long-term survival. Discussion: The main therapeutic option for SIADH in cancer patients is the treatment of the underlying disease, and its correction depends almost exclusively on a good response to oncological therapy. The initiation of immunotherapy at the time of severe hyponatremia occurrence led to its remission as well as the remission of the other two episodes of hyponatremia, which the patient presented throughout the evolution of the disease, demonstrating an obvious causal relationship between SIADH and the favorable response to immunotherapy. Conclusions: Each patient must be approached individually, taking into account the various particular aspects. Immunotherapy proves to be the innovative treatment that contributes to increasing the survival of patients with metastatic non-small cell lung cancer and to increasing their quality of life. MDPI 2023-05-30 /pmc/articles/PMC10303290/ /pubmed/37374062 http://dx.doi.org/10.3390/life13061279 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Rahnea-Nita, Roxana-Andreea
Stoian, Alexandru-Rares
Anghel, Rodica-Maricela
Rebegea, Laura-Florentina
Ciuhu, Anda-Natalia
Bacinschi, Xenia-Elena
Zgura, Anca-Florina
Trifanescu, Oana-Gabriela
Toma, Radu-Valeriu
Constantin, Georgiana Bianca
Rahnea-Nita, Gabriela
The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
title The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
title_full The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
title_fullStr The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
title_full_unstemmed The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
title_short The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
title_sort efficacy of immunotherapy in long-term survival in non-small cell lung cancer (nsclc) associated with the syndrome of inappropriate antidiuretic hormone secretion (siadh)
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303290/
https://www.ncbi.nlm.nih.gov/pubmed/37374062
http://dx.doi.org/10.3390/life13061279
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