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Prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep
BACKGROUND: The prevalence of prenatal depressive symptoms has more than doubled during the COVID-19 pandemic, raising substantial concerns about child outcomes including sleep problems and altered brain development. The objective of this work was to determine relationships between prenatal depressi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303328/ https://www.ncbi.nlm.nih.gov/pubmed/37390922 http://dx.doi.org/10.1016/j.jad.2023.06.054 |
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author | Donnici, Claire Tomfohr-Madsen, Lianne Long, Xiangyu Manning, Kathryn Y. Giesbrecht, Gerald Lebel, Catherine |
author_facet | Donnici, Claire Tomfohr-Madsen, Lianne Long, Xiangyu Manning, Kathryn Y. Giesbrecht, Gerald Lebel, Catherine |
author_sort | Donnici, Claire |
collection | PubMed |
description | BACKGROUND: The prevalence of prenatal depressive symptoms has more than doubled during the COVID-19 pandemic, raising substantial concerns about child outcomes including sleep problems and altered brain development. The objective of this work was to determine relationships between prenatal depressive symptoms, infant brain network structure, and infant sleep. METHODS: Pregnant mothers and their infant children (n = 66; 26 female children) were recruited as part of the Pregnancy during the Pandemic (PdP) study. Maternal depressive symptoms were measured in pregnancy and postpartum. At 3 months of age, infants underwent diffusion magnetic resonance imaging and infant sleep was evaluated. Using tractography, we calculated structural connectivity matrices for the default mode (DMN) and limbic networks. We examined associations between graph theory metrics of infant brain networks and prenatal maternal depressive symptoms, with infant sleep as a moderator. RESULTS: Prenatal depressive symptoms were negatively related to average DMN clustering coefficient and local efficiency in infant brains. Infant sleep duration was related to DMN global efficiency and moderated the relationship between prenatal depressive symptoms and density of limbic connections. Infants who slept less had a more negative relationship between prenatal depressive symptoms and local brain connectivity. CONCLUSIONS: Prenatal depressive symptoms appear to impact early topological development in brain networks important for emotion regulation. In the limbic network, sleep duration moderated this relationship, suggesting sleep may play a role in infant brain network development. |
format | Online Article Text |
id | pubmed-10303328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103033282023-06-29 Prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep Donnici, Claire Tomfohr-Madsen, Lianne Long, Xiangyu Manning, Kathryn Y. Giesbrecht, Gerald Lebel, Catherine J Affect Disord Research Paper BACKGROUND: The prevalence of prenatal depressive symptoms has more than doubled during the COVID-19 pandemic, raising substantial concerns about child outcomes including sleep problems and altered brain development. The objective of this work was to determine relationships between prenatal depressive symptoms, infant brain network structure, and infant sleep. METHODS: Pregnant mothers and their infant children (n = 66; 26 female children) were recruited as part of the Pregnancy during the Pandemic (PdP) study. Maternal depressive symptoms were measured in pregnancy and postpartum. At 3 months of age, infants underwent diffusion magnetic resonance imaging and infant sleep was evaluated. Using tractography, we calculated structural connectivity matrices for the default mode (DMN) and limbic networks. We examined associations between graph theory metrics of infant brain networks and prenatal maternal depressive symptoms, with infant sleep as a moderator. RESULTS: Prenatal depressive symptoms were negatively related to average DMN clustering coefficient and local efficiency in infant brains. Infant sleep duration was related to DMN global efficiency and moderated the relationship between prenatal depressive symptoms and density of limbic connections. Infants who slept less had a more negative relationship between prenatal depressive symptoms and local brain connectivity. CONCLUSIONS: Prenatal depressive symptoms appear to impact early topological development in brain networks important for emotion regulation. In the limbic network, sleep duration moderated this relationship, suggesting sleep may play a role in infant brain network development. Elsevier B.V. 2023-06-28 /pmc/articles/PMC10303328/ /pubmed/37390922 http://dx.doi.org/10.1016/j.jad.2023.06.054 Text en © 2023 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Research Paper Donnici, Claire Tomfohr-Madsen, Lianne Long, Xiangyu Manning, Kathryn Y. Giesbrecht, Gerald Lebel, Catherine Prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep |
title | Prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep |
title_full | Prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep |
title_fullStr | Prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep |
title_full_unstemmed | Prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep |
title_short | Prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep |
title_sort | prenatal depressive symptoms are associated with altered structural brain networks in infants and moderated by infant sleep |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303328/ https://www.ncbi.nlm.nih.gov/pubmed/37390922 http://dx.doi.org/10.1016/j.jad.2023.06.054 |
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