Screening Libraries to Discover Molecular Design Principles for the Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers Derived from Plant Phenolic Acids †

Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of extraordinarily efficient COVID-19 vaccines. The four-component lipid nanoparticles (LNPs), containing phospholipids, PEG-conjugated lipids, cholesterol, and ionizable lipids, co-assembled with mRNA via a micro...

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Detalles Bibliográficos
Autores principales: Lu, Juncheng, Atochina-Vasserman, Elena N., Maurya, Devendra S., Shalihin, Muhammad Irhash, Zhang, Dapeng, Chenna, Srijay S., Adamson, Jasper, Liu, Matthew, Shah, Habib Ur Rehman, Shah, Honey, Xiao, Qi, Queeley, Bryn, Ona, Nathan A., Reagan, Erin K., Ni, Houping, Sahoo, Dipankar, Peterca, Mihai, Weissman, Drew, Percec, Virgil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303357/
https://www.ncbi.nlm.nih.gov/pubmed/37376020
http://dx.doi.org/10.3390/pharmaceutics15061572

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