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Synthesis and Preclinical Evaluation of Novel (68)Ga-Labeled (R)-Pyrrolidin-2-yl-boronic Acid-Based PET Tracers for Fibroblast Activation Protein-Targeted Cancer Imaging

Fibroblast activation protein (FAP) is a membrane-tethered serine protease overexpressed in the reactive stromal fibroblasts of >90% human carcinomas, which makes it a promising target for developing radiopharmaceuticals for the imaging and therapy of carcinomas. Here, we synthesized two novel (R...

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Detalles Bibliográficos
Autores principales:	Bendre, Shreya, Kuo, Hsiou-Ting, Merkens, Helen, Zhang, Zhengxing, Wong, Antonio A. W. L., Bénard, François, Lin, Kuo-Shyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303363/ https://www.ncbi.nlm.nih.gov/pubmed/37375746 http://dx.doi.org/10.3390/ph16060798

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