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In vivo dynamics and regulation of DNA G-quadruplex structures in mammals

G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by guanine-rich sequence folding, and G4 has been computationally predicted to exist in a wide range of species. Substantial evidence has supported the formation of endogenous G4 (eG4) in living cells and revealed its regula...

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Autores principales: Zhang, Ze-Hao, Qian, Sheng Hu, Wei, Dengguo, Chen, Zhen-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303365/
https://www.ncbi.nlm.nih.gov/pubmed/37381029
http://dx.doi.org/10.1186/s13578-023-01074-8
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author Zhang, Ze-Hao
Qian, Sheng Hu
Wei, Dengguo
Chen, Zhen-Xia
author_facet Zhang, Ze-Hao
Qian, Sheng Hu
Wei, Dengguo
Chen, Zhen-Xia
author_sort Zhang, Ze-Hao
collection PubMed
description G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by guanine-rich sequence folding, and G4 has been computationally predicted to exist in a wide range of species. Substantial evidence has supported the formation of endogenous G4 (eG4) in living cells and revealed its regulatory dynamics and critical roles in several important biological processes, making eG4 a regulator of gene expression perturbation and a promising therapeutic target in disease biology. Here, we reviewed the methods for prediction of potential G4 sequences (PQS) and detection of eG4s. We also highlighted the factors affecting the dynamics of eG4s and the effects of eG4 dynamics. Finally, we discussed the future applications of eG4 dynamics in disease therapy.
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spelling pubmed-103033652023-06-29 In vivo dynamics and regulation of DNA G-quadruplex structures in mammals Zhang, Ze-Hao Qian, Sheng Hu Wei, Dengguo Chen, Zhen-Xia Cell Biosci Review G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by guanine-rich sequence folding, and G4 has been computationally predicted to exist in a wide range of species. Substantial evidence has supported the formation of endogenous G4 (eG4) in living cells and revealed its regulatory dynamics and critical roles in several important biological processes, making eG4 a regulator of gene expression perturbation and a promising therapeutic target in disease biology. Here, we reviewed the methods for prediction of potential G4 sequences (PQS) and detection of eG4s. We also highlighted the factors affecting the dynamics of eG4s and the effects of eG4 dynamics. Finally, we discussed the future applications of eG4 dynamics in disease therapy. BioMed Central 2023-06-28 /pmc/articles/PMC10303365/ /pubmed/37381029 http://dx.doi.org/10.1186/s13578-023-01074-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Ze-Hao
Qian, Sheng Hu
Wei, Dengguo
Chen, Zhen-Xia
In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
title In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
title_full In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
title_fullStr In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
title_full_unstemmed In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
title_short In vivo dynamics and regulation of DNA G-quadruplex structures in mammals
title_sort in vivo dynamics and regulation of dna g-quadruplex structures in mammals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303365/
https://www.ncbi.nlm.nih.gov/pubmed/37381029
http://dx.doi.org/10.1186/s13578-023-01074-8
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