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Ion Channels and Personalized Medicine in Gynecological Cancers

Targeted therapy against cancer plays a key role in delivering safer and more efficient treatments. In the last decades, ion channels have been studied for their participation in oncogenic processes because their aberrant expression and/or function have been associated with different types of malign...

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Autores principales: Ramírez, Ana, Ogonaga-Borja, Ingrid, Acosta, Brenda, Chiliquinga, Andrea Jazmín, de la Garza, Jaime, Gariglio, Patricio, Ocádiz-Delgado, Rodolfo, Bañuelos, Cecilia, Camacho, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303675/
https://www.ncbi.nlm.nih.gov/pubmed/37375748
http://dx.doi.org/10.3390/ph16060800
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author Ramírez, Ana
Ogonaga-Borja, Ingrid
Acosta, Brenda
Chiliquinga, Andrea Jazmín
de la Garza, Jaime
Gariglio, Patricio
Ocádiz-Delgado, Rodolfo
Bañuelos, Cecilia
Camacho, Javier
author_facet Ramírez, Ana
Ogonaga-Borja, Ingrid
Acosta, Brenda
Chiliquinga, Andrea Jazmín
de la Garza, Jaime
Gariglio, Patricio
Ocádiz-Delgado, Rodolfo
Bañuelos, Cecilia
Camacho, Javier
author_sort Ramírez, Ana
collection PubMed
description Targeted therapy against cancer plays a key role in delivering safer and more efficient treatments. In the last decades, ion channels have been studied for their participation in oncogenic processes because their aberrant expression and/or function have been associated with different types of malignancies, including ovarian, cervical, and endometrial cancer. The altered expression or function of several ion channels have been associated with tumor aggressiveness, increased proliferation, migration, invasion, and metastasis of cancer cells and with poor prognosis in gynecological cancer patients. Most ion channels are integral membrane proteins easily accessible by drugs. Interestingly, a plethora of ion channel blockers have demonstrated anticancer activity. Consequently, some ion channels have been proposed as oncogenes, cancer, and prognostic biomarkers, as well as therapeutic targets in gynecological cancers. Here, we review the association of ion channels with the properties of cancer cells in these tumors, which makes them very promising candidates to be exploited in personalized medicine. The detailed analysis of the expression pattern and function of ion channels could help to improve the clinical outcomes in gynecological cancer patients.
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spelling pubmed-103036752023-06-29 Ion Channels and Personalized Medicine in Gynecological Cancers Ramírez, Ana Ogonaga-Borja, Ingrid Acosta, Brenda Chiliquinga, Andrea Jazmín de la Garza, Jaime Gariglio, Patricio Ocádiz-Delgado, Rodolfo Bañuelos, Cecilia Camacho, Javier Pharmaceuticals (Basel) Review Targeted therapy against cancer plays a key role in delivering safer and more efficient treatments. In the last decades, ion channels have been studied for their participation in oncogenic processes because their aberrant expression and/or function have been associated with different types of malignancies, including ovarian, cervical, and endometrial cancer. The altered expression or function of several ion channels have been associated with tumor aggressiveness, increased proliferation, migration, invasion, and metastasis of cancer cells and with poor prognosis in gynecological cancer patients. Most ion channels are integral membrane proteins easily accessible by drugs. Interestingly, a plethora of ion channel blockers have demonstrated anticancer activity. Consequently, some ion channels have been proposed as oncogenes, cancer, and prognostic biomarkers, as well as therapeutic targets in gynecological cancers. Here, we review the association of ion channels with the properties of cancer cells in these tumors, which makes them very promising candidates to be exploited in personalized medicine. The detailed analysis of the expression pattern and function of ion channels could help to improve the clinical outcomes in gynecological cancer patients. MDPI 2023-05-29 /pmc/articles/PMC10303675/ /pubmed/37375748 http://dx.doi.org/10.3390/ph16060800 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ramírez, Ana
Ogonaga-Borja, Ingrid
Acosta, Brenda
Chiliquinga, Andrea Jazmín
de la Garza, Jaime
Gariglio, Patricio
Ocádiz-Delgado, Rodolfo
Bañuelos, Cecilia
Camacho, Javier
Ion Channels and Personalized Medicine in Gynecological Cancers
title Ion Channels and Personalized Medicine in Gynecological Cancers
title_full Ion Channels and Personalized Medicine in Gynecological Cancers
title_fullStr Ion Channels and Personalized Medicine in Gynecological Cancers
title_full_unstemmed Ion Channels and Personalized Medicine in Gynecological Cancers
title_short Ion Channels and Personalized Medicine in Gynecological Cancers
title_sort ion channels and personalized medicine in gynecological cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303675/
https://www.ncbi.nlm.nih.gov/pubmed/37375748
http://dx.doi.org/10.3390/ph16060800
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