Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis

Background: Patients with tuberculosis (TB) may develop multi-organ failure and require admission to intensive care. In these cases, the mortality rates are as high as 78% and may be caused by suboptimal serum concentrations of first-line TB drugs. This study aims to compare the pharmacokinetics of...

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Detalles Bibliográficos
Autores principales: Beraldi-Magalhaes, Francisco, Parker, Suzanne L., Sanches, Cristina, Garcia, Leandro Sousa, Souza Carvalho, Brenda Karoline, Costa, Amanda Araujo, Fachi, Mariana Millan, de Liz, Marcus Vinicius, de Souza, Alexandra Brito, Safe, Izabella Picinin, Pontarolo, Roberto, Wallis, Steven, Lipman, Jeffrey, Roberts, Jason A., Cordeiro-Santos, Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303681/
https://www.ncbi.nlm.nih.gov/pubmed/37368730
http://dx.doi.org/10.3390/tropicalmed8060312

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