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New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition

The Paeonia suffruticosa, known as ‘Feng Dan’, has been used for thousands of years in traditional Chinese medicine. In our chemical investigation on the root bark of the plant, five new phenolic dimers, namely, paeobenzofuranones A–E (1–5), were characterized. Their structures were determined using...

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Autores principales: Meng, Qianqian, Tong, Shunyao, Zhao, Yuqing, Peng, Xingrong, Li, Zhenghui, Feng, Tao, Liu, Jikai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303828/
https://www.ncbi.nlm.nih.gov/pubmed/37375146
http://dx.doi.org/10.3390/molecules28124590
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author Meng, Qianqian
Tong, Shunyao
Zhao, Yuqing
Peng, Xingrong
Li, Zhenghui
Feng, Tao
Liu, Jikai
author_facet Meng, Qianqian
Tong, Shunyao
Zhao, Yuqing
Peng, Xingrong
Li, Zhenghui
Feng, Tao
Liu, Jikai
author_sort Meng, Qianqian
collection PubMed
description The Paeonia suffruticosa, known as ‘Feng Dan’, has been used for thousands of years in traditional Chinese medicine. In our chemical investigation on the root bark of the plant, five new phenolic dimers, namely, paeobenzofuranones A–E (1–5), were characterized. Their structures were determined using spectroscopic analysis including 1D and 2D NMR, HRESIMS, UV, and IR, as well as ECD calculations. Compounds 2, 4, and 5 showed cytotoxicity against three human cancer cell lines, with IC(50) values ranging from 6.7 to 25.1 μM. Compounds 1 and 2 showed certain inhibitory activity on NO production. To the best of our knowledge, the benzofuranone dimers and their cytotoxicity of P. suffruticosa are reported for the first time in this paper.
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spelling pubmed-103038282023-06-29 New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition Meng, Qianqian Tong, Shunyao Zhao, Yuqing Peng, Xingrong Li, Zhenghui Feng, Tao Liu, Jikai Molecules Article The Paeonia suffruticosa, known as ‘Feng Dan’, has been used for thousands of years in traditional Chinese medicine. In our chemical investigation on the root bark of the plant, five new phenolic dimers, namely, paeobenzofuranones A–E (1–5), were characterized. Their structures were determined using spectroscopic analysis including 1D and 2D NMR, HRESIMS, UV, and IR, as well as ECD calculations. Compounds 2, 4, and 5 showed cytotoxicity against three human cancer cell lines, with IC(50) values ranging from 6.7 to 25.1 μM. Compounds 1 and 2 showed certain inhibitory activity on NO production. To the best of our knowledge, the benzofuranone dimers and their cytotoxicity of P. suffruticosa are reported for the first time in this paper. MDPI 2023-06-06 /pmc/articles/PMC10303828/ /pubmed/37375146 http://dx.doi.org/10.3390/molecules28124590 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meng, Qianqian
Tong, Shunyao
Zhao, Yuqing
Peng, Xingrong
Li, Zhenghui
Feng, Tao
Liu, Jikai
New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
title New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
title_full New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
title_fullStr New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
title_full_unstemmed New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
title_short New Phenolic Dimers from Plant Paeonia suffruticosa and Their Cytotoxicity and NO Production Inhibition
title_sort new phenolic dimers from plant paeonia suffruticosa and their cytotoxicity and no production inhibition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303828/
https://www.ncbi.nlm.nih.gov/pubmed/37375146
http://dx.doi.org/10.3390/molecules28124590
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