The NLRP3 inflammasome: contributions to inflammation-related diseases

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of imm...

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Autores principales: Chen, Ying, Ye, Xingyan, Escames, Germaine, Lei, Wangrui, Zhang, Xin, Li, Meng, Jing, Tong, Yao, Yu, Qiu, Zhenye, Wang, Zheng, Acuña-Castroviejo, Darío, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303833/
https://www.ncbi.nlm.nih.gov/pubmed/37370025
http://dx.doi.org/10.1186/s11658-023-00462-9
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author Chen, Ying
Ye, Xingyan
Escames, Germaine
Lei, Wangrui
Zhang, Xin
Li, Meng
Jing, Tong
Yao, Yu
Qiu, Zhenye
Wang, Zheng
Acuña-Castroviejo, Darío
Yang, Yang
author_facet Chen, Ying
Ye, Xingyan
Escames, Germaine
Lei, Wangrui
Zhang, Xin
Li, Meng
Jing, Tong
Yao, Yu
Qiu, Zhenye
Wang, Zheng
Acuña-Castroviejo, Darío
Yang, Yang
author_sort Chen, Ying
collection PubMed
description The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer’s disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.
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spelling pubmed-103038332023-06-29 The NLRP3 inflammasome: contributions to inflammation-related diseases Chen, Ying Ye, Xingyan Escames, Germaine Lei, Wangrui Zhang, Xin Li, Meng Jing, Tong Yao, Yu Qiu, Zhenye Wang, Zheng Acuña-Castroviejo, Darío Yang, Yang Cell Mol Biol Lett Review Letter The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer’s disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment. BioMed Central 2023-06-27 /pmc/articles/PMC10303833/ /pubmed/37370025 http://dx.doi.org/10.1186/s11658-023-00462-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Letter
Chen, Ying
Ye, Xingyan
Escames, Germaine
Lei, Wangrui
Zhang, Xin
Li, Meng
Jing, Tong
Yao, Yu
Qiu, Zhenye
Wang, Zheng
Acuña-Castroviejo, Darío
Yang, Yang
The NLRP3 inflammasome: contributions to inflammation-related diseases
title The NLRP3 inflammasome: contributions to inflammation-related diseases
title_full The NLRP3 inflammasome: contributions to inflammation-related diseases
title_fullStr The NLRP3 inflammasome: contributions to inflammation-related diseases
title_full_unstemmed The NLRP3 inflammasome: contributions to inflammation-related diseases
title_short The NLRP3 inflammasome: contributions to inflammation-related diseases
title_sort nlrp3 inflammasome: contributions to inflammation-related diseases
topic Review Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303833/
https://www.ncbi.nlm.nih.gov/pubmed/37370025
http://dx.doi.org/10.1186/s11658-023-00462-9
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