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Recent Population Dynamics of Japanese Encephalitis Virus
Japanese encephalitis virus (JEV) causes acute viral encephalitis in humans and reproductive disorders in pigs. JEV emerged during the 1870s in Japan, and since that time, JEV has been transmitted exclusively throughout Asia, according to known reporting and sequencing records. A recent JEV outbreak...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304036/ https://www.ncbi.nlm.nih.gov/pubmed/37376612 http://dx.doi.org/10.3390/v15061312 |
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author | Xu, Jinpeng Wahaab, Abdul Khan, Sawar Nawaz, Mohsin Anwar, Muhammad Naveed Liu, Ke Wei, Jianchao Hameed, Muddassar Ma, Zhiyong |
author_facet | Xu, Jinpeng Wahaab, Abdul Khan, Sawar Nawaz, Mohsin Anwar, Muhammad Naveed Liu, Ke Wei, Jianchao Hameed, Muddassar Ma, Zhiyong |
author_sort | Xu, Jinpeng |
collection | PubMed |
description | Japanese encephalitis virus (JEV) causes acute viral encephalitis in humans and reproductive disorders in pigs. JEV emerged during the 1870s in Japan, and since that time, JEV has been transmitted exclusively throughout Asia, according to known reporting and sequencing records. A recent JEV outbreak occurred in Australia, affecting commercial piggeries across different temperate southern Australian states, and causing confirmed infections in humans. A total of 47 human cases and 7 deaths were reported. The recent evolving situation of JEV needs to be reported due to its continuous circulation in endemic regions and spread to non-endemics areas. Here, we reconstructed the phylogeny and population dynamics of JEV using recent JEV isolates for the future perception of disease spread. Phylogenetic analysis shows the most recent common ancestor occurred about 2993 years ago (YA) (95% Highest posterior density (HPD), 2433 to 3569). Our results of the Bayesian skyline plot (BSP) demonstrates that JEV demography lacks fluctuations for the last two decades, but it shows that JEV genetic diversity has increased during the last ten years. This indicates the potential JEV replication in the reservoir host, which is helping it to maintain its genetic diversity and to continue its dispersal into non-endemic areas. The continuous spread in Asia and recent detection from Australia further support these findings. Therefore, an enhanced surveillance system is needed along with precautionary measures such as regular vaccination and mosquito control to avoid future JEV outbreaks. |
format | Online Article Text |
id | pubmed-10304036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103040362023-06-29 Recent Population Dynamics of Japanese Encephalitis Virus Xu, Jinpeng Wahaab, Abdul Khan, Sawar Nawaz, Mohsin Anwar, Muhammad Naveed Liu, Ke Wei, Jianchao Hameed, Muddassar Ma, Zhiyong Viruses Communication Japanese encephalitis virus (JEV) causes acute viral encephalitis in humans and reproductive disorders in pigs. JEV emerged during the 1870s in Japan, and since that time, JEV has been transmitted exclusively throughout Asia, according to known reporting and sequencing records. A recent JEV outbreak occurred in Australia, affecting commercial piggeries across different temperate southern Australian states, and causing confirmed infections in humans. A total of 47 human cases and 7 deaths were reported. The recent evolving situation of JEV needs to be reported due to its continuous circulation in endemic regions and spread to non-endemics areas. Here, we reconstructed the phylogeny and population dynamics of JEV using recent JEV isolates for the future perception of disease spread. Phylogenetic analysis shows the most recent common ancestor occurred about 2993 years ago (YA) (95% Highest posterior density (HPD), 2433 to 3569). Our results of the Bayesian skyline plot (BSP) demonstrates that JEV demography lacks fluctuations for the last two decades, but it shows that JEV genetic diversity has increased during the last ten years. This indicates the potential JEV replication in the reservoir host, which is helping it to maintain its genetic diversity and to continue its dispersal into non-endemic areas. The continuous spread in Asia and recent detection from Australia further support these findings. Therefore, an enhanced surveillance system is needed along with precautionary measures such as regular vaccination and mosquito control to avoid future JEV outbreaks. MDPI 2023-06-02 /pmc/articles/PMC10304036/ /pubmed/37376612 http://dx.doi.org/10.3390/v15061312 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Xu, Jinpeng Wahaab, Abdul Khan, Sawar Nawaz, Mohsin Anwar, Muhammad Naveed Liu, Ke Wei, Jianchao Hameed, Muddassar Ma, Zhiyong Recent Population Dynamics of Japanese Encephalitis Virus |
title | Recent Population Dynamics of Japanese Encephalitis Virus |
title_full | Recent Population Dynamics of Japanese Encephalitis Virus |
title_fullStr | Recent Population Dynamics of Japanese Encephalitis Virus |
title_full_unstemmed | Recent Population Dynamics of Japanese Encephalitis Virus |
title_short | Recent Population Dynamics of Japanese Encephalitis Virus |
title_sort | recent population dynamics of japanese encephalitis virus |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304036/ https://www.ncbi.nlm.nih.gov/pubmed/37376612 http://dx.doi.org/10.3390/v15061312 |
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