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Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment

Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal. It is usually due to opportunistic infections caused by bacteria, viruses, fungi, and protozoa resulting in a decrease in number and impairment in th...

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Autores principales: Justiz-Vaillant, Angel A., Gopaul, Darren, Akpaka, Patrick Eberechi, Soodeen, Sachin, Arozarena Fundora, Rodolfo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304095/
https://www.ncbi.nlm.nih.gov/pubmed/37375091
http://dx.doi.org/10.3390/microorganisms11061589
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author Justiz-Vaillant, Angel A.
Gopaul, Darren
Akpaka, Patrick Eberechi
Soodeen, Sachin
Arozarena Fundora, Rodolfo
author_facet Justiz-Vaillant, Angel A.
Gopaul, Darren
Akpaka, Patrick Eberechi
Soodeen, Sachin
Arozarena Fundora, Rodolfo
author_sort Justiz-Vaillant, Angel A.
collection PubMed
description Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal. It is usually due to opportunistic infections caused by bacteria, viruses, fungi, and protozoa resulting in a decrease in number and impairment in the function of T and B cells. Autosomal, X-linked, and sporadic forms exist. Evidence of recurrent opportunistic infections and lymphopenia very early in life should prompt immunological investigation and suspicion of this rare disorder. Adequate stem cell transplantation is the treatment of choice. This review aimed to provide a comprehensive approach to the microorganisms associated with severe combined immunodeficiency (SCID) and its management. We describe SCID as a syndrome and summarize the different microorganisms that affect children and how they can be investigated and treated.
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spelling pubmed-103040952023-06-29 Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment Justiz-Vaillant, Angel A. Gopaul, Darren Akpaka, Patrick Eberechi Soodeen, Sachin Arozarena Fundora, Rodolfo Microorganisms Review Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal. It is usually due to opportunistic infections caused by bacteria, viruses, fungi, and protozoa resulting in a decrease in number and impairment in the function of T and B cells. Autosomal, X-linked, and sporadic forms exist. Evidence of recurrent opportunistic infections and lymphopenia very early in life should prompt immunological investigation and suspicion of this rare disorder. Adequate stem cell transplantation is the treatment of choice. This review aimed to provide a comprehensive approach to the microorganisms associated with severe combined immunodeficiency (SCID) and its management. We describe SCID as a syndrome and summarize the different microorganisms that affect children and how they can be investigated and treated. MDPI 2023-06-15 /pmc/articles/PMC10304095/ /pubmed/37375091 http://dx.doi.org/10.3390/microorganisms11061589 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Justiz-Vaillant, Angel A.
Gopaul, Darren
Akpaka, Patrick Eberechi
Soodeen, Sachin
Arozarena Fundora, Rodolfo
Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment
title Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment
title_full Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment
title_fullStr Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment
title_full_unstemmed Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment
title_short Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment
title_sort severe combined immunodeficiency—classification, microbiology association and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304095/
https://www.ncbi.nlm.nih.gov/pubmed/37375091
http://dx.doi.org/10.3390/microorganisms11061589
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