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Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment
Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal. It is usually due to opportunistic infections caused by bacteria, viruses, fungi, and protozoa resulting in a decrease in number and impairment in th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304095/ https://www.ncbi.nlm.nih.gov/pubmed/37375091 http://dx.doi.org/10.3390/microorganisms11061589 |
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author | Justiz-Vaillant, Angel A. Gopaul, Darren Akpaka, Patrick Eberechi Soodeen, Sachin Arozarena Fundora, Rodolfo |
author_facet | Justiz-Vaillant, Angel A. Gopaul, Darren Akpaka, Patrick Eberechi Soodeen, Sachin Arozarena Fundora, Rodolfo |
author_sort | Justiz-Vaillant, Angel A. |
collection | PubMed |
description | Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal. It is usually due to opportunistic infections caused by bacteria, viruses, fungi, and protozoa resulting in a decrease in number and impairment in the function of T and B cells. Autosomal, X-linked, and sporadic forms exist. Evidence of recurrent opportunistic infections and lymphopenia very early in life should prompt immunological investigation and suspicion of this rare disorder. Adequate stem cell transplantation is the treatment of choice. This review aimed to provide a comprehensive approach to the microorganisms associated with severe combined immunodeficiency (SCID) and its management. We describe SCID as a syndrome and summarize the different microorganisms that affect children and how they can be investigated and treated. |
format | Online Article Text |
id | pubmed-10304095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103040952023-06-29 Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment Justiz-Vaillant, Angel A. Gopaul, Darren Akpaka, Patrick Eberechi Soodeen, Sachin Arozarena Fundora, Rodolfo Microorganisms Review Severe combined immunodeficiency (SCID) is a primary inherited immunodeficiency disease that presents before the age of three months and can be fatal. It is usually due to opportunistic infections caused by bacteria, viruses, fungi, and protozoa resulting in a decrease in number and impairment in the function of T and B cells. Autosomal, X-linked, and sporadic forms exist. Evidence of recurrent opportunistic infections and lymphopenia very early in life should prompt immunological investigation and suspicion of this rare disorder. Adequate stem cell transplantation is the treatment of choice. This review aimed to provide a comprehensive approach to the microorganisms associated with severe combined immunodeficiency (SCID) and its management. We describe SCID as a syndrome and summarize the different microorganisms that affect children and how they can be investigated and treated. MDPI 2023-06-15 /pmc/articles/PMC10304095/ /pubmed/37375091 http://dx.doi.org/10.3390/microorganisms11061589 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Justiz-Vaillant, Angel A. Gopaul, Darren Akpaka, Patrick Eberechi Soodeen, Sachin Arozarena Fundora, Rodolfo Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment |
title | Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment |
title_full | Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment |
title_fullStr | Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment |
title_full_unstemmed | Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment |
title_short | Severe Combined Immunodeficiency—Classification, Microbiology Association and Treatment |
title_sort | severe combined immunodeficiency—classification, microbiology association and treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304095/ https://www.ncbi.nlm.nih.gov/pubmed/37375091 http://dx.doi.org/10.3390/microorganisms11061589 |
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