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Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites

Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to dise...

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Detalles Bibliográficos
Autores principales: Moianos, Dimitrios, Prifti, Georgia-Myrto, Makri, Maria, Zoidis, Grigoris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304105/
https://www.ncbi.nlm.nih.gov/pubmed/37375848
http://dx.doi.org/10.3390/ph16060901
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author Moianos, Dimitrios
Prifti, Georgia-Myrto
Makri, Maria
Zoidis, Grigoris
author_facet Moianos, Dimitrios
Prifti, Georgia-Myrto
Makri, Maria
Zoidis, Grigoris
author_sort Moianos, Dimitrios
collection PubMed
description Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to disease therapy. Metal-chelating agents have been expansively studied as antivirals and antiparasitics, resulting in important classes of metal-dependent enzyme inhibitors. This review provides the recent advances in targeting the metalloenzymes of viruses and parasites that impose a significant burden on global public health, including influenza A and B, hepatitis B and C, and human immunodeficiency viruses as well as Trypanosoma brucei and Trypanosoma cruzi.
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spelling pubmed-103041052023-06-29 Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites Moianos, Dimitrios Prifti, Georgia-Myrto Makri, Maria Zoidis, Grigoris Pharmaceuticals (Basel) Review Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to disease therapy. Metal-chelating agents have been expansively studied as antivirals and antiparasitics, resulting in important classes of metal-dependent enzyme inhibitors. This review provides the recent advances in targeting the metalloenzymes of viruses and parasites that impose a significant burden on global public health, including influenza A and B, hepatitis B and C, and human immunodeficiency viruses as well as Trypanosoma brucei and Trypanosoma cruzi. MDPI 2023-06-19 /pmc/articles/PMC10304105/ /pubmed/37375848 http://dx.doi.org/10.3390/ph16060901 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moianos, Dimitrios
Prifti, Georgia-Myrto
Makri, Maria
Zoidis, Grigoris
Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
title Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
title_full Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
title_fullStr Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
title_full_unstemmed Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
title_short Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
title_sort targeting metalloenzymes: the “achilles’ heel” of viruses and parasites
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304105/
https://www.ncbi.nlm.nih.gov/pubmed/37375848
http://dx.doi.org/10.3390/ph16060901
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