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Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to dise...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304105/ https://www.ncbi.nlm.nih.gov/pubmed/37375848 http://dx.doi.org/10.3390/ph16060901 |
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author | Moianos, Dimitrios Prifti, Georgia-Myrto Makri, Maria Zoidis, Grigoris |
author_facet | Moianos, Dimitrios Prifti, Georgia-Myrto Makri, Maria Zoidis, Grigoris |
author_sort | Moianos, Dimitrios |
collection | PubMed |
description | Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to disease therapy. Metal-chelating agents have been expansively studied as antivirals and antiparasitics, resulting in important classes of metal-dependent enzyme inhibitors. This review provides the recent advances in targeting the metalloenzymes of viruses and parasites that impose a significant burden on global public health, including influenza A and B, hepatitis B and C, and human immunodeficiency viruses as well as Trypanosoma brucei and Trypanosoma cruzi. |
format | Online Article Text |
id | pubmed-10304105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103041052023-06-29 Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites Moianos, Dimitrios Prifti, Georgia-Myrto Makri, Maria Zoidis, Grigoris Pharmaceuticals (Basel) Review Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic functions, including protein degradation, nucleic acid modification, and many others. Given the impact of infectious diseases on human health, inhibiting metalloenzymes offers an attractive approach to disease therapy. Metal-chelating agents have been expansively studied as antivirals and antiparasitics, resulting in important classes of metal-dependent enzyme inhibitors. This review provides the recent advances in targeting the metalloenzymes of viruses and parasites that impose a significant burden on global public health, including influenza A and B, hepatitis B and C, and human immunodeficiency viruses as well as Trypanosoma brucei and Trypanosoma cruzi. MDPI 2023-06-19 /pmc/articles/PMC10304105/ /pubmed/37375848 http://dx.doi.org/10.3390/ph16060901 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Moianos, Dimitrios Prifti, Georgia-Myrto Makri, Maria Zoidis, Grigoris Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites |
title | Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites |
title_full | Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites |
title_fullStr | Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites |
title_full_unstemmed | Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites |
title_short | Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites |
title_sort | targeting metalloenzymes: the “achilles’ heel” of viruses and parasites |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304105/ https://www.ncbi.nlm.nih.gov/pubmed/37375848 http://dx.doi.org/10.3390/ph16060901 |
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