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Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides
The long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption ha...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304191/ https://www.ncbi.nlm.nih.gov/pubmed/37368581 http://dx.doi.org/10.3390/toxics11060482 |
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author | Garshin, Aleksandr Altynova, Nazym Djangalina, Erika Khamdiyeva, Ozada Baratzhanova, Gulminyam Tolebaeva, Anar Zhaniyazov, Zhasulan Khussainova, Elmira Cakir-Kiefer, Céline Jurjanz, Stefan Delannoy, Matthieu Djansugurova, Leyla |
author_facet | Garshin, Aleksandr Altynova, Nazym Djangalina, Erika Khamdiyeva, Ozada Baratzhanova, Gulminyam Tolebaeva, Anar Zhaniyazov, Zhasulan Khussainova, Elmira Cakir-Kiefer, Céline Jurjanz, Stefan Delannoy, Matthieu Djansugurova, Leyla |
author_sort | Garshin, Aleksandr |
collection | PubMed |
description | The long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment of the general exposure risks of the local population was carried out using the analysis of pollutants in food products and the average levels of their consumption in the region. The cohort risk evaluation revealed that the greatest risk was associated with the regular consumption of cucumbers, pears, bell peppers, meat, and milk. The new model to estimate individual risks of long-term pesticide pollution was proposed as a calculation of the combined action of 9 risk factors, including individual genotypes, age, lifestyle, and personal pesticide consumption rates. The analysis of the predictive ability of this model showed that the final score for individual health risks corresponded to the development of chronic diseases. A high level of chromosomal aberrations was evidenced for individual genetic risk manifestations. The combined influence of all risk factors revealed contributions of 24.7% for health status and 14.2% for genetic status, while other impacts go to all unaccounted factors. |
format | Online Article Text |
id | pubmed-10304191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103041912023-06-29 Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides Garshin, Aleksandr Altynova, Nazym Djangalina, Erika Khamdiyeva, Ozada Baratzhanova, Gulminyam Tolebaeva, Anar Zhaniyazov, Zhasulan Khussainova, Elmira Cakir-Kiefer, Céline Jurjanz, Stefan Delannoy, Matthieu Djansugurova, Leyla Toxics Article The long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption habits and lifestyle characteristics. An assessment of the general exposure risks of the local population was carried out using the analysis of pollutants in food products and the average levels of their consumption in the region. The cohort risk evaluation revealed that the greatest risk was associated with the regular consumption of cucumbers, pears, bell peppers, meat, and milk. The new model to estimate individual risks of long-term pesticide pollution was proposed as a calculation of the combined action of 9 risk factors, including individual genotypes, age, lifestyle, and personal pesticide consumption rates. The analysis of the predictive ability of this model showed that the final score for individual health risks corresponded to the development of chronic diseases. A high level of chromosomal aberrations was evidenced for individual genetic risk manifestations. The combined influence of all risk factors revealed contributions of 24.7% for health status and 14.2% for genetic status, while other impacts go to all unaccounted factors. MDPI 2023-05-25 /pmc/articles/PMC10304191/ /pubmed/37368581 http://dx.doi.org/10.3390/toxics11060482 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Garshin, Aleksandr Altynova, Nazym Djangalina, Erika Khamdiyeva, Ozada Baratzhanova, Gulminyam Tolebaeva, Anar Zhaniyazov, Zhasulan Khussainova, Elmira Cakir-Kiefer, Céline Jurjanz, Stefan Delannoy, Matthieu Djansugurova, Leyla Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides |
title | Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides |
title_full | Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides |
title_fullStr | Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides |
title_full_unstemmed | Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides |
title_short | Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides |
title_sort | individual risk assessment for population living on the territories long-term polluted by organochlorine pesticides |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304191/ https://www.ncbi.nlm.nih.gov/pubmed/37368581 http://dx.doi.org/10.3390/toxics11060482 |
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