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Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study

BACKGROUND: Osteosarcoma is the most prevalent primary malignant bone tumor. The primary treatment for osteosarcoma is a combination of chemotherapy and surgery. However, there has been no recent progress in the role of chemotherapy in improving the long-term survival of osteosarcoma patients. This...

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Autores principales: Wang, Jinkui, Li, Mujie, Guo, Peng, He, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304229/
https://www.ncbi.nlm.nih.gov/pubmed/37370182
http://dx.doi.org/10.1186/s13018-023-03922-2
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author Wang, Jinkui
Li, Mujie
Guo, Peng
He, Dawei
author_facet Wang, Jinkui
Li, Mujie
Guo, Peng
He, Dawei
author_sort Wang, Jinkui
collection PubMed
description BACKGROUND: Osteosarcoma is the most prevalent primary malignant bone tumor. The primary treatment for osteosarcoma is a combination of chemotherapy and surgery. However, there has been no recent progress in the role of chemotherapy in improving the long-term survival of osteosarcoma patients. This study aims to analyze the factors that affect chemotherapy in patients with osteosarcoma and explore the challenges and survival benefits of chemotherapy. METHODS: Patient data were downloaded from The Surveillance, Epidemiology, and End Results database. Univariable and multivariable logistic regressions were used to analyze the factors affecting patients receiving chemotherapy. Kaplan–Meier (K–M) curve was used to analyze the survival benefit of chemotherapy in patients with osteosarcoma. Finally, we used annual percentage change (APC) to evaluate the annual changes in chemotherapy treatment rates and trends in 5-year survival rates in osteosarcoma patients. RESULTS: A total of 2157 osteosarcoma patients were included, of which 1887 patients received chemotherapy. Factors affecting patients receiving chemotherapy included age, primary tumor site, tumor size, N stage, M stage, and surgery. The K–M curve showed that older patients could benefit significantly from chemotherapy. The APC results showed no significant change in the chemotherapy treatment rate and 5-year overall survival rate of osteosarcoma patients. CONCLUSION: Chemotherapy is an irreplaceable treatment for patients with osteosarcoma. However, in recent years, there has been no significant progress in chemotherapy for osteosarcoma, and the long-term survival of patients has not improved significantly. New chemotherapeutic drugs or drug delivery systems are urgently needed to improve the prognosis of patients with osteosarcoma.
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spelling pubmed-103042292023-06-29 Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study Wang, Jinkui Li, Mujie Guo, Peng He, Dawei J Orthop Surg Res Research Article BACKGROUND: Osteosarcoma is the most prevalent primary malignant bone tumor. The primary treatment for osteosarcoma is a combination of chemotherapy and surgery. However, there has been no recent progress in the role of chemotherapy in improving the long-term survival of osteosarcoma patients. This study aims to analyze the factors that affect chemotherapy in patients with osteosarcoma and explore the challenges and survival benefits of chemotherapy. METHODS: Patient data were downloaded from The Surveillance, Epidemiology, and End Results database. Univariable and multivariable logistic regressions were used to analyze the factors affecting patients receiving chemotherapy. Kaplan–Meier (K–M) curve was used to analyze the survival benefit of chemotherapy in patients with osteosarcoma. Finally, we used annual percentage change (APC) to evaluate the annual changes in chemotherapy treatment rates and trends in 5-year survival rates in osteosarcoma patients. RESULTS: A total of 2157 osteosarcoma patients were included, of which 1887 patients received chemotherapy. Factors affecting patients receiving chemotherapy included age, primary tumor site, tumor size, N stage, M stage, and surgery. The K–M curve showed that older patients could benefit significantly from chemotherapy. The APC results showed no significant change in the chemotherapy treatment rate and 5-year overall survival rate of osteosarcoma patients. CONCLUSION: Chemotherapy is an irreplaceable treatment for patients with osteosarcoma. However, in recent years, there has been no significant progress in chemotherapy for osteosarcoma, and the long-term survival of patients has not improved significantly. New chemotherapeutic drugs or drug delivery systems are urgently needed to improve the prognosis of patients with osteosarcoma. BioMed Central 2023-06-27 /pmc/articles/PMC10304229/ /pubmed/37370182 http://dx.doi.org/10.1186/s13018-023-03922-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Wang, Jinkui
Li, Mujie
Guo, Peng
He, Dawei
Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study
title Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study
title_full Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study
title_fullStr Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study
title_full_unstemmed Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study
title_short Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study
title_sort survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304229/
https://www.ncbi.nlm.nih.gov/pubmed/37370182
http://dx.doi.org/10.1186/s13018-023-03922-2
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