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Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) tends to undergo distant metastasis, especially liver metastasis, leading to a poor prognosis. Metabolic remodelling and epigenetic reprogramming are two important hallmarks of malignant tumours and participate in regulating PDAC tumorigenesis and...

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Detalles Bibliográficos
Autores principales:	Yang, Jinshou, Ren, Bo, Ren, Jie, Yang, Gang, Fang, Yuan, Wang, Xing, Zhou, Feihan, You, Lei, Zhao, Yupei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304235/ https://www.ncbi.nlm.nih.gov/pubmed/37370109 http://dx.doi.org/10.1186/s13046-023-02698-x

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