Adenylosuccinic Acid: An Orphan Drug with Untapped Potential

Adenylosuccinic acid (ASA) is an orphan drug that was once investigated for clinical application in Duchenne muscular dystrophy (DMD). Endogenous ASA participates in purine recycling and energy homeostasis but might also be crucial for averting inflammation and other forms of cellular stress during...

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Autores principales: Rybalka, Emma, Kourakis, Stephanie, Bonsett, Charles A., Moghadaszadeh, Behzad, Beggs, Alan H., Timpani, Cara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304260/
https://www.ncbi.nlm.nih.gov/pubmed/37375769
http://dx.doi.org/10.3390/ph16060822
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author Rybalka, Emma
Kourakis, Stephanie
Bonsett, Charles A.
Moghadaszadeh, Behzad
Beggs, Alan H.
Timpani, Cara A.
author_facet Rybalka, Emma
Kourakis, Stephanie
Bonsett, Charles A.
Moghadaszadeh, Behzad
Beggs, Alan H.
Timpani, Cara A.
author_sort Rybalka, Emma
collection PubMed
description Adenylosuccinic acid (ASA) is an orphan drug that was once investigated for clinical application in Duchenne muscular dystrophy (DMD). Endogenous ASA participates in purine recycling and energy homeostasis but might also be crucial for averting inflammation and other forms of cellular stress during intense energy demand and maintaining tissue biomass and glucose disposal. This article documents the known biological functions of ASA and explores its potential application for the treatment of neuromuscular and other chronic diseases.
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spelling pubmed-103042602023-06-29 Adenylosuccinic Acid: An Orphan Drug with Untapped Potential Rybalka, Emma Kourakis, Stephanie Bonsett, Charles A. Moghadaszadeh, Behzad Beggs, Alan H. Timpani, Cara A. Pharmaceuticals (Basel) Perspective Adenylosuccinic acid (ASA) is an orphan drug that was once investigated for clinical application in Duchenne muscular dystrophy (DMD). Endogenous ASA participates in purine recycling and energy homeostasis but might also be crucial for averting inflammation and other forms of cellular stress during intense energy demand and maintaining tissue biomass and glucose disposal. This article documents the known biological functions of ASA and explores its potential application for the treatment of neuromuscular and other chronic diseases. MDPI 2023-05-31 /pmc/articles/PMC10304260/ /pubmed/37375769 http://dx.doi.org/10.3390/ph16060822 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Rybalka, Emma
Kourakis, Stephanie
Bonsett, Charles A.
Moghadaszadeh, Behzad
Beggs, Alan H.
Timpani, Cara A.
Adenylosuccinic Acid: An Orphan Drug with Untapped Potential
title Adenylosuccinic Acid: An Orphan Drug with Untapped Potential
title_full Adenylosuccinic Acid: An Orphan Drug with Untapped Potential
title_fullStr Adenylosuccinic Acid: An Orphan Drug with Untapped Potential
title_full_unstemmed Adenylosuccinic Acid: An Orphan Drug with Untapped Potential
title_short Adenylosuccinic Acid: An Orphan Drug with Untapped Potential
title_sort adenylosuccinic acid: an orphan drug with untapped potential
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304260/
https://www.ncbi.nlm.nih.gov/pubmed/37375769
http://dx.doi.org/10.3390/ph16060822
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AT beggsalanh adenylosuccinicacidanorphandrugwithuntappedpotential
AT timpanicaraa adenylosuccinicacidanorphandrugwithuntappedpotential

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