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Systemic Associations with Keratoconus

Keratoconus is a disease of the cornea that results in progressive steepening and thinning of the cornea and subsequent vision loss. It nearly always presents as a bilateral disease, suggesting that there is an underlying abnormality of the corneas that becomes manifest with time. However, the mecha...

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Autores principales: Unni, Prasida, Lee, Hyunjoo Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304343/
https://www.ncbi.nlm.nih.gov/pubmed/37374145
http://dx.doi.org/10.3390/life13061363
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author Unni, Prasida
Lee, Hyunjoo Jean
author_facet Unni, Prasida
Lee, Hyunjoo Jean
author_sort Unni, Prasida
collection PubMed
description Keratoconus is a disease of the cornea that results in progressive steepening and thinning of the cornea and subsequent vision loss. It nearly always presents as a bilateral disease, suggesting that there is an underlying abnormality of the corneas that becomes manifest with time. However, the mechanisms underlying the development of keratoconus are largely unknown. Associations reported between keratoconus and systemic diseases are abundant in the literature, and the list of possible associations is very long. We found that atopy, Down syndrome, and various connective tissue diseases were the most frequently cited associations in our broad literature search. Additionally, Diabetes Mellitus has been increasingly studied as a possible protective factor against keratoconus. In this review, we have summarized the evidence for and against these particular systemic conditions and keratoconus and have discussed some of the implications of keratoconus patients having these conditions.
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spelling pubmed-103043432023-06-29 Systemic Associations with Keratoconus Unni, Prasida Lee, Hyunjoo Jean Life (Basel) Review Keratoconus is a disease of the cornea that results in progressive steepening and thinning of the cornea and subsequent vision loss. It nearly always presents as a bilateral disease, suggesting that there is an underlying abnormality of the corneas that becomes manifest with time. However, the mechanisms underlying the development of keratoconus are largely unknown. Associations reported between keratoconus and systemic diseases are abundant in the literature, and the list of possible associations is very long. We found that atopy, Down syndrome, and various connective tissue diseases were the most frequently cited associations in our broad literature search. Additionally, Diabetes Mellitus has been increasingly studied as a possible protective factor against keratoconus. In this review, we have summarized the evidence for and against these particular systemic conditions and keratoconus and have discussed some of the implications of keratoconus patients having these conditions. MDPI 2023-06-10 /pmc/articles/PMC10304343/ /pubmed/37374145 http://dx.doi.org/10.3390/life13061363 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Unni, Prasida
Lee, Hyunjoo Jean
Systemic Associations with Keratoconus
title Systemic Associations with Keratoconus
title_full Systemic Associations with Keratoconus
title_fullStr Systemic Associations with Keratoconus
title_full_unstemmed Systemic Associations with Keratoconus
title_short Systemic Associations with Keratoconus
title_sort systemic associations with keratoconus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304343/
https://www.ncbi.nlm.nih.gov/pubmed/37374145
http://dx.doi.org/10.3390/life13061363
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