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Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities

N-heterocyclic scaffolds represent a privileged architecture in the process of drug design and development. It has widespread occurrence in synthetic and natural products, either those that are established or progressing as potent drug candidates. Additionally, numerous novel N-heterocyclic analogue...

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Detalles Bibliográficos
Autores principales: Majee, Suman, Shilpa, Sarav, Mansi, Banik, Bimal Krishna, Ray, Devalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304377/
https://www.ncbi.nlm.nih.gov/pubmed/37375820
http://dx.doi.org/10.3390/ph16060873
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author Majee, Suman
Shilpa
Sarav, Mansi
Banik, Bimal Krishna
Ray, Devalina
author_facet Majee, Suman
Shilpa
Sarav, Mansi
Banik, Bimal Krishna
Ray, Devalina
author_sort Majee, Suman
collection PubMed
description N-heterocyclic scaffolds represent a privileged architecture in the process of drug design and development. It has widespread occurrence in synthetic and natural products, either those that are established or progressing as potent drug candidates. Additionally, numerous novel N-heterocyclic analogues with remarkable physiological significance and extended pharmaceutical applications are escalating progressively. Hence, the classical synthetic protocols need to be improvised according to modern requirements for efficient and eco-friendly approaches. Numerous methodologies and technologies emerged to address the green and sustainable production of various pharmaceutically and medicinally important N-heterocyclic compounds in last few years. In this context, the current review unveils greener alternatives for direct access to categorically differentiated N-heterocyclic derivatives and its application in the establishment of biologically active potent molecules for drug design. The green and sustainable methods accentuated in this review includes microwave-assisted reactions, solvent-free approaches, heterogeneous catalysis, ultrasound reactions, and biocatalysis.
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spelling pubmed-103043772023-06-29 Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities Majee, Suman Shilpa Sarav, Mansi Banik, Bimal Krishna Ray, Devalina Pharmaceuticals (Basel) Review N-heterocyclic scaffolds represent a privileged architecture in the process of drug design and development. It has widespread occurrence in synthetic and natural products, either those that are established or progressing as potent drug candidates. Additionally, numerous novel N-heterocyclic analogues with remarkable physiological significance and extended pharmaceutical applications are escalating progressively. Hence, the classical synthetic protocols need to be improvised according to modern requirements for efficient and eco-friendly approaches. Numerous methodologies and technologies emerged to address the green and sustainable production of various pharmaceutically and medicinally important N-heterocyclic compounds in last few years. In this context, the current review unveils greener alternatives for direct access to categorically differentiated N-heterocyclic derivatives and its application in the establishment of biologically active potent molecules for drug design. The green and sustainable methods accentuated in this review includes microwave-assisted reactions, solvent-free approaches, heterogeneous catalysis, ultrasound reactions, and biocatalysis. MDPI 2023-06-13 /pmc/articles/PMC10304377/ /pubmed/37375820 http://dx.doi.org/10.3390/ph16060873 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Majee, Suman
Shilpa
Sarav, Mansi
Banik, Bimal Krishna
Ray, Devalina
Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities
title Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities
title_full Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities
title_fullStr Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities
title_full_unstemmed Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities
title_short Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities
title_sort recent advances in the green synthesis of active n-heterocycles and their biological activities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304377/
https://www.ncbi.nlm.nih.gov/pubmed/37375820
http://dx.doi.org/10.3390/ph16060873
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